Now showing items 100-119 of 483

    • Cyclic Marinopyrrole Derivatives as Disruptors of Mcl-1 and Bcl-xL Binding to Bim 

      Cheng, Chunwei; Liu, Yan; Balasis, Maria E.; Simmons, Nicholas L.; Li, Jerry; Song, Hao; Pan, Lili; Qin, Yong; Nicolaou, K.C.; Sebti, Said M.; Li, Rongshi (2014)
      A series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA ...
    • Cytotoxicity and variant cellular internalization behavior of water-soluble sulfonated nanographene sheets in liver cancer cells 

      Corr, Stuart J.; Raoof, Mustafa; Cisneros, Brandon T.; Kuznetsov, Oleksandr; Massey, Katheryn; Kaluarachchi, Warna D.; Cheney, Matthew A.; Billups, Edward W.; Wilson, Lon J.; Curley, Steven A. (2013)
      Highly exfoliated sulfonated graphene sheets (SGSs), an alternative to graphene oxide and graphene derivatives, were synthesized, characterized, and applied to liver cancer cells in vitro. Cytotoxicity profiles were obtained ...
    • De novo prediction of human chromosome structures: Epigenetic marking patterns encode genome architecture 

      Di Pierro, Michele; Cheng, Ryan R.; Aiden, Erez Lieberman; Wolynes, Peter G.; Onuchic, José N. (2017)
      Inside the cell nucleus, genomes fold into organized structures that are characteristic of cell type. Here, we show that this chromatin architecture can be predicted de novo using epigenetic data derived from chromatin ...
    • Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse 

      Choi, Mi-Ran; Bardhan, Rizia; Stanton-Maxey, Katie J.; Badve, Sunil; Nakshatri, Harikrishna; Stantz, Keith M.; Cao, Ning; Halas, Naomi J.; Clare, Susan E. (2012)
      As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood-brain barrier (BBB) represents a major ...
    • Density matrix embedding from broken symmetry lattice mean fields 

      Bulik, Ireneusz W.; Scuseria, Gustavo E.; Dukelsky, Jorge (2014)
      Several variants of the recently proposed density matrix embedding theory (DMET) [G. Knizia and G. K-L. Chan, Phys. Rev. Lett. 109, 186404 (2012)] are formulated and tested. We show that spin symmetry breaking of the lattice ...
    • Design of a Pd–Au Nitrite Reduction Catalyst by Identifying and Optimizing Active Ensembles 

      Li, Hao; Guo, Sujin; Shin, Kihyun; Wong, Michael S.; Henkelman, Graeme (2019)
      Nitrate (NO3–) is a ubiquitous contaminant in groundwater that causes serious public health issues around the world. Though various strategies are able to reduce NO3– to nitrite (NO2–), a rational catalyst design strategy ...
    • Detecting the Biopolymer Behavior of Graphene Nanoribbons in Aqueous Solution 

      Wijeratne, Sithara S.; Penev, Evgeni S.; Lu, Wei; Li, Jingqiang; Duque, Amanda L.; Yakobson, Boris I.; Tour, James M.; Kiang, Ching-Hwa (2016)
      Graphene nanoribbons (GNR), can be prepared in bulk quantities for large-area applications by reducing the product from the lengthwise oxidative unzipping of multiwalled carbon nanotubes (MWNT). Recently, the biomaterials ...
    • Development of morphogen gradient: The role of dimension and discreteness 

      Teimouri, Hamid; Kolomeisky, Anatoly B. (2014)
      The fundamental processes of biological development are governed by multiple signaling molecules that create non-uniform concentration profiles known as morphogen gradients. It is widely believed that the establishment of ...
    • Development of Morphogen Gradients with Spatially Varying Degradation Rates 

      Teimouri, Hamid; Bozorgui, Behnaz; Kolomeisky, Anatoly B. (2016)
      Successful biological development via spatial and temporal regulations of cell differentiation relies on the action of multiple signaling molecules that are known as morphogens. It is now well established that biological ...
    • Diatoms at >5000 Meters in the Quelccaya Summit Dome Glacier, Peru 

      Fritz, Sherilyn C.; Brinson, Bruce E.; Billups, W.E.; Thompson, Lonnie G. (2015)
      Diatoms were found in late Holocene age ice-core samples recovered from the Quelccaya Summit Dome in the tropical Andes of Peru and were imaged by environmental scanning electron microscopy and identified. Freshwater diatoms ...
    • Dichotomous noise models of gene switches 

      Potoyan, Davit A.; Wolynes, Peter G. (2015)
      Molecular noise in gene regulatory networks has two intrinsic components, one part being due to fluctuations caused by the birth and death of protein or mRNA molecules which are often present in small numbers and the other ...
    • Direct and Stereospecific Synthesis of N-H and N-Alkyl Aziridines from Unactivated Olefins Using Hydroxylamine-O-Sulfonic Acids 

      Ma, Zhiwei; Zhou, Zhe; Kürti, László (2017)
      A RhII-catalyzed direct and stereospecific N-H- and N-alkyl aziridination of olefins is reported that uses hydroxylamine-O-sulfonic acids as inexpensive, readily available, and nitro group-free aminating reagents. Unactivated ...
    • Direct Plasmon-Driven Photoelectrocatalysis 

      Robatjazi, Hossein; Bahauddin, Shah Mohammad; Doiron, Chloe; Thomann, Isabell (2015)
      Harnessing the energy from hot charge carriers is an emerging research area with the potential to improve energy conversion technologies. Here we present a novel plasmonic photoelectrode architecture carefully designed to ...
    • Directed motion of periodically driven molecular motors: A graph-theoretical approach 

      Akimov, Alexey V.; Mandal, Dibyendu; Chernyak, Vladimir Y.; Sinitsyn, Nikolai A. (2013-01-11)
      We propose a numerical algorithm for calculation of quantized directed motion of a stochastic system of interacting particles induced by periodic changes of control parameters on the graph of microstates. As a main ...
    • Dirhodium-catalyzed C-H arene amination using hydroxylamines 

      Paudyal, Mahesh P.; Adebesin, Adeniyi Michael; Burt, Scott R.; Ess, Daniel H.; Ma, Zhiwei; Kürti, László; Falck, John R. (2016)
      Primary and N-alkyl arylamine motifs are key functional groups in pharmaceuticals, agrochemicals, and functional materials, as well as in bioactive natural products. However, there is a dearth of generally applicable methods ...
    • Discrete Kinetic Models from Funneled Energy Landscape Simulations 

      Schafer, Nicholas P.; Hoffman, Ryan M.B.; Burger, Anat; Craig, Patricio O.; Komives, Elizabeth A. (2012)
      A general method for facilitating the interpretation of computer simulations of protein folding with minimally frustrated energy landscapes is detailed and applied to a designed ankyrin repeat protein (4ANK). In the method, ...
    • Distinguishing mechanisms underlying EMT tristability 

      Jia, Dongya; Jolly, Mohit K; Tripathi, Satyendra C; Den Hollander, Petra; Huang, Bin; Lu, Mingyang; Celiktas, Muge; Ramirez-Peña, Esmeralda; Ben-Jacob, Eshel; Onuchic, José N; Hanash, Samir M; Mani, Sendurai A; Levine, Herbert (2017)
      Abstract Background The Epithelial-Mesenchymal Transition (EMT) endows epithelial-looking cells with enhanced migratory ability during embryonic development and tissue ...
    • Distributed Cooperative Communications in Wireless Networks 

      Khojastepour, Mohammad (2005-01-01)
      The primary challenge in communication over wireless networks, unlike wireline networks, is the existence of interference and channel variations (fading). Having more users at higher data rates means that current ...
    • Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers 

      Fuller, Franklin D.; Gul, Sheraz; Chatterjee, Ruchira; Burgie, E. Sethe; Young, Iris D.; Lebrette, Hugo; Srinivas, Vivek; Brewster, Aaron S.; Michels-Clark, Tara; Clinger, Jonathan A.; Andi, Babak; Ibrahim, Mohamed; Pastor, Ernest; de Lichtenberg, Casper; Hussein, Rana; Pollock, Christopher J.; Zhang, Miao; Stan, Claudiu A.; Kroll, Thomas; Fransson, Thomas; Weninger, Clemens; Kubin, Markus; Aller, Pierre; Lassalle, Louise; Bräuer, Philipp; Miller, Mitchell D.; Amin, Muhamed; Koroidov, Sergey; Roessler, Christian G.; Allaire, Marc; Sierra, Raymond G.; Docker, Peter T.; Glownia, James M.; Nelson, Silke; Koglin, Jason E.; Zhu, Diling; Chollet, Matthieu; Song, Sanghoon; Lemke, Henrik; Liang, Mengning; Sokaras, Dimosthenis; Alonso-Mori, Roberto; Zouni, Athina; Messinger, Johannes; Bergmann, Uwe; Boal, Amie K.; Bollinger, J. Martin Jr.; Krebs, Carsten; Högbom, Martin; Phillips, George N. Jr.; Vierstra,, Richard D.; Sauter, Nicholas K.; Orville, Allen M.; Kern, Jan; Yachandra, Vittal K.; Yano, Junko (2017)
      X-ray crystallography at X-ray free-electron laser sources is a powerful method for studying macromolecules at biologically relevant temperatures. Moreover, when combined with complementary techniques like X-ray emission ...
    • Drug-Triggered and Cross-Linked Self-Assembling Nanofibrous Hydrogels 

      Kumar, Vivek A.; Shi, Siyu; Wang, Benjamin K.; Li, I-Che; Jalan, Abhishek A.; Sarkar, Biplab; Wickremasinghe, Navindee C.; Hartgerink, Jeffrey D. (2015)
      Self-assembly of multidomain peptides (MDP) can be tailored to carry payloads that modulate the extracellular environment. Controlled release of growth factors, cytokines, and small-molecule drugs allows for unique control ...