Now showing items 1-3 of 3

    • Genetic and Chemical Activation of TFEB Mediates Clearance of Aggregated α-Synuclein 

      Kilpatrick, Kiri; Zeng, Yimeng; Hancock, Tommy; Segatori, Laura (2015)
      Aggregation of α-synuclein (α-syn) is associated with the development of a number of neurodegenerative diseases, including Parkinson’s disease (PD). The formation of α-syn aggregates results from aberrant accumulation of ...
    • Quantitative Analysis of α-Synuclein Solubility in Living Cells Using Split GFP Complementation 

      Kothawala, Ahmed; Kilpatrick, Kiri; Novoa, Jose Andres; Segatori, Laura (2012)
      Presently incurable, Parkinson's disease (PD) is the most common neurodegenerative movement disorder and affects 1% of the population over 60 years of age. The hallmarks of PD pathogenesis are the loss of dopaminergic ...
    • TFEB regulates lysosomal proteostasis 

      Song, Wensi; Wang, Fan; Savini, Marzia; Ake, Ashley; di Ronza, Alberto; Sardiello, Marco; Segatori, Laura (2013)
      Loss-of-function diseases are often caused by destabilizing mutations that lead to protein misfolding and degradation. Modulating the innate protein homeostasis (proteostasis) capacity may lead to rescue of native folding ...