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dc.contributor.advisor Wilson, Lon J.
dc.creatorAnanta Narayanan, Jeyarama Subramanian
dc.date.accessioned 2012-07-03T22:49:03Z
dc.date.available 2012-07-03T22:49:03Z
dc.date.created 2011-05
dc.date.issued 2011
dc.identifier.citation Ananta Narayanan, Jeyarama Subramanian. "Carbon-Based Nanostructures as Advanced Contrast Agents for Magnetic Resonance Imaging." (2011) Diss., Rice University. https://hdl.handle.net/1911/64375.
dc.identifier.urihttps://hdl.handle.net/1911/64375
dc.description.abstract Superparamagnetic carbon-based nanostructures are presented as contrast agents (CAs) for advanced imaging applications such as cellular and molecular imaging using magnetic resonance imaging (MRI). Gadolinium-loaded, ultra-short single-walled carbon nanotubes (gadonanotubes; GNTs) are shown to have extremely high rl relaxivities (contrast enhancement efficacy), especially at low-magnetic field strengths. The inherent lipophilicity of GNTs provides them the ability to image cells at low magnetic field strength. A carboxylated dextran-coated GNT (GadoDex) has been synthesized and proposed as a new biocompatible high-performance MRI CA. The rl relaxivity is ca. 20 times greater than for other paramagnetic Gd-based CAs. This enhanced relaxivity for GadoDex is due to the synergistic effects of an increased molecular tumbling time ('tR) and a faster proton exchange rate ('tm). GNTs also exhibit very large transverse relaxivities (r2) at high magnetic fields ~ 3 T). The dependence of the transverse relaxation rates (especially R2 *) of labeled cells on GNT concentration offers the possibility to quantify cell population in vivo using R2 * mapping. The cell-labeling efficiency and high transverse relaxivities of GNTs has enabled the first non-iron oxide-based single-cell imaging using MRI.
dc.format.extent 100 pp
dc.format.mimetype application/pdf
dc.language.iso eng
dc.subjectChemistry
dc.title Carbon-Based Nanostructures as Advanced Contrast Agents for Magnetic Resonance Imaging
dc.identifier.digital AnantaN
dc.type.genre Thesis
dc.type.material Text
thesis.degree.department Chemistry
thesis.degree.discipline Natural Sciences
thesis.degree.grantor Rice University
thesis.degree.level Doctoral
thesis.degree.name Doctor of Philosophy


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