Show simple item record

dc.contributor.advisor Dickinson, Mary E.
dc.creatorGao, Liang
dc.date.accessioned 2011-07-25T02:07:25Z
dc.date.available 2011-07-25T02:07:25Z
dc.date.issued 2010
dc.identifier.citation Gao, Liang. "Nanoshells in vivo imaging using two-photon excitation microscopy." (2010) Master’s Thesis, Rice University. https://hdl.handle.net/1911/62198.
dc.identifier.urihttps://hdl.handle.net/1911/62198
dc.description.abstract This thesis describes the development and optical characterization of near infrared (NIR) gold nanoshells for the use as luminescent contrast agents for applications in small animal blood vessel imaging. Two types of gold-silica nanoshells excitable by NIR lasers are investigated: Type 1 nanoshells can be excited with a sub-mum NW laser, whereas Type 2 nanoshells can be excited with a NW laser in the micrometer range. Using NIR microscopy as an imaging platform, ex vivo and in vivo experiments are conducted to determine the efficacy of these nanoshells as suitable contrast agents. Specifically, individual particles of Type 1 nanoshells are successfully imaged and shown to provide bright optical contrast for blood vessel imaging both ex vivo and in vivo, while the Type 2 nanoshells are clearly imaged within the blood vessels ex vivo. These positive results suggest a promising possibility of developing a new class of contrast agents for deep tissue imaging and improving the imaging depth of NIR imaging techniques.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.subjectNanotechnology
Biochemistry
Physiology
Biophysics
dc.title Nanoshells in vivo imaging using two-photon excitation microscopy
dc.type Thesis
dc.type.material Text
thesis.degree.department Bioengineering
thesis.degree.discipline Engineering
thesis.degree.grantor Rice University
thesis.degree.level Masters
thesis.degree.name Master of Science
dc.identifier.callno THESIS BIOENG. 2010 GAO


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record