Show simple item record

dc.contributor.advisor Kavraki, Lydia E.
dc.creatorBryant, Drew
dc.date.accessioned 2011-07-25T01:50:54Z
dc.date.available 2011-07-25T01:50:54Z
dc.date.issued 2010
dc.identifier.citation Bryant, Drew. "Mapping the structural landscape of protein families with geometric feature vectors." (2010) Master’s Thesis, Rice University. https://hdl.handle.net/1911/61956.
dc.identifier.urihttps://hdl.handle.net/1911/61956
dc.description.abstract This thesis describes two key results that can be used separately or in combination for protein function analysis. The Family-wise Analysis of SubStructural Templates (FASST) method uses all-against-all substructure comparison to determine family-wide sub-group organization by quantifying the substructural variation within a protein family. The results demonstrate examples of automatically determined sub-groups that can be linked to phylogenetic distance between family members, segregation by ligation state, and organization by ancestry among convergent protein lineages. The Motif Ensemble Statistical Hypothesis (MESH) framework constructs a representative template for each of the subgroups determined by FASST to build motif ensembles that are shown through a series of function prediction experiments to improve the function prediction power of existing templates. This work provides an unbiased, automated assessment of the structural variability of identified substructures among protein structure families and a technique for exploring the relation of substructural variation to protein function.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.subjectBiology
Bioinformatics
Computer science
Applied sciences
dc.title Mapping the structural landscape of protein families with geometric feature vectors
dc.type Thesis
dc.type.material Text
thesis.degree.department Biology
thesis.degree.discipline Natural Sciences
thesis.degree.grantor Rice University
thesis.degree.level Masters
thesis.degree.name Master of Science


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record