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dc.contributor.advisor West, Jennifer L.
dc.creatorMorton, Jennifer Garner
dc.date.accessioned 2011-07-25T01:38:49Z
dc.date.available 2011-07-25T01:38:49Z
dc.date.issued 2009
dc.identifier.urihttps://hdl.handle.net/1911/61860
dc.description.abstract This thesis describes the development of photothermal nanoshell therapy activated by proteases. Hirsch et al. previously showed that the optical spectrum of crosslinked nanoshells within the UV-visible range reveals a broader, red-shifted, and lower peak absorbance as compared to disperse nanoshells. As described in this thesis, studies showed this decrease in absorbance corresponds with a lower temperature change upon laser irradiation of the nanoshells. Near infrared (NIR)-absorbing silica-gold nanoshells were crosslinked with a proteolytically degradable linker, resulting in a broadening, red-shifting, and decrease of the peak absorbance. After collagenase was added to the crosslinked nanoshells, the peak absorbance increased, suggesting degradation of the linker and subsequent dispersion of the nanoshells. The results described here suggest that this may be applied to protease-activation in vivo within the tumor in an effort to increase tumor specificity and to protect surrounding normal tissue.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.subjectBiomedical engineering
dc.title Protease-activated nanoshell therapy
dc.type.genre Thesis
dc.type.material Text
thesis.degree.department Bioengineering
thesis.degree.discipline Engineering
thesis.degree.grantor Rice University
thesis.degree.level Masters
thesis.degree.name Master of Science
dc.identifier.citation Morton, Jennifer Garner. "Protease-activated nanoshell therapy." (2009) Master’s Thesis, Rice University. https://hdl.handle.net/1911/61860.


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