Browsing Statistics Publications by Title
Now showing items 56-75 of 100
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Making an R package
(2010-11-09) -
MEXIT: Maximal un-coupling times for stochastic processes
(2019)Classical coupling constructions arrange for copies of the same Markov process started at two different initial states to become equal as soon as possible. In this paper, we consider an alternative coupling framework in ... -
Microarray experiments and factors which affect their reliability
(2015)Oligonucleotide microarrays belong to the basic tools of molecular biology and allow for simultaneous assessment of the expression level of thousands of genes. Analysis of microarray data is however very complex, requiring ... -
Mixed Effects Models for Resampled Network Statistics Improves Statistical Power to Find Differences in Multi-Subject Functional Connectivity
(2016)Many complex brain disorders, such as autism spectrum disorders, exhibit a wide range of symptoms and disability. To understand how brain communication is impaired in such conditions, functional connectivity studies seek ... -
Model-based clustering of large networks
(2013)We describe a network clustering framework, based on finite mixture models, that can be applied to discrete-valued networks with hundreds of thousands of nodes and billions of edge variables. Relative to other recent ... -
Modeling neutral evolution using an in nite-allele Markov branching process
(2013)We consider an in nite-allele Markov branching process (IAMBP). Our main focus is the frequency spectrum of this process, i.e., the proportion of alleles having a given number of copies at a speci ed time point. We derive ... -
Modeling the Natural History and Detection of Lung Cancer Based on Smoking Behavior
(2014)In this study, we developed a method for modeling the progression and detection of lung cancer based on the smoking behavior at an individual level. The model allows obtaining the characteristics of lung cancer in a ... -
Molecular pathway identification using biological network-regularized logistic models
(2013)Background: Selecting genes and pathways indicative of disease is a central problem in computational biology. This problem is especially challenging when parsing multi-dimensional genomic data. A number of tools, such as ... -
Multitype Bellman-Harris branching model provides biological predictors of early stages of adult hippocampal neurogenesis
(2017)Abstract Background Adult hippocampal neurogenesis, the process of formation of new neurons, occurs throughout life in the hippocampus. New neurons have been associated ... -
A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells
(2016)The advent of functional genomics has enabled the genome-wide characterization of the molecular state of cells and tissues, virtually at every level of biological organization. The difficulty in organizing and mining this ... -
Neural Networks of Colored Sequence Synesthesia
(2013)Synesthesia is a condition in which normal stimuli can trigger anomalous associations. In this study,weexploit synesthesia to understand how the synesthetic experience can be explained by subtle changes in network properties. ... -
NF-κB and IRF pathways: cross-regulation on target genes promoter level
(2015)Background: The NF-κB and IRF transcription factor families are major players in inflammation and antiviral response and act as two major effectors of the innate immune response (IIR). The regulatory mechanisms of activation ... -
On the Reproducibility of TCGA Ovarian Cancer MicroRNA Profiles
(2014)Dysregulated microRNA (miRNA) expression is a well-established feature of human cancer. However, the role of specific miRNAs in determining cancer outcomes remains unclear. Using Level 3 expression data from the Cancer ... -
On the time for Brownian motion to visit every point on a circle
(2016)Consider a Wiener process W on a circle of circumference L. We prove the rather surprising result that the Laplace transform of the distribution of the first time, θL, when the Wiener process has visited every point of the ... -
Point source influence on observed extreme pollution levels in a monitoring network
(2014)This paper presents a strategy to quantify the influence major point sources in a region have on extreme pollution values observed at each of the monitors in the network. We focus on the number of hours in a day the levels ... -
Prediction using hierarchical data: Applications for automated detection of cervical cancer
(2015)Although the Papanicolaou smear has been successful in decreasing cervical cancer incidence in the developed world, there exist many challenges for implementation in the developing world. Quantitative cytology, a semi-automated ... -
Prenatal exposure to cadmium and cotinine and CpG island DNA methylation in mother-infant pairs
(2015)A precise biological mechanism by which cadmium acts as a developmental toxicant is unknown but is suggested to include an epigenetic basis. In prior work, we analyzed CpG island methylation levels within gene promoters ... -
Proteomic analyses reveal distinct chromatin‐associated and soluble transcription factor complexes
(2015)The current knowledge on how transcription factors (TFs), the ultimate targets and executors of cellular signalling pathways, are regulated by protein–protein interactions remains limited. Here, we performed proteomics ... -
Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-κB signaling at the single cell level
(2018)Elevated temperature induces the heat shock (HS) response, which modulates cell proliferation, apoptosis, the immune and inflammatory responses. However, specific mechanisms linking the HS response pathways to major cellular ... -
Regularized partial least squares with an application to NMR spectroscopy
(2013)High-dimensional data common in genomics, proteomics, and chemometrics often contains complicated correlation structures. Recently, partial least squares (PLS) and Sparse PLS methods have gained attention in these areas ...
