Browsing Statistics Publications by Title
Now showing items 31-50 of 100
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Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity
(2017)Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific conformations that activate only subsets of signaling effectors. In this study, to identify molecular motifs playing ... -
Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity
(2017)Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific conformations that activate only subsets of signaling effectors. In this study, to identify molecular motifs playing ... -
Evolutionary Action Score of TP53 Coding Variants Is Predictive of Platinum Response in Head and Neck Cancer Patients
(2015)TP53 is the most frequently altered gene in head and neck squamous cell carcinoma (HNSCC), with mutations occurring in over two thirds of cases; however, the predictive response of these mutations to cisplatin-based therapy ... -
Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer
(2015)TP53 is the most frequently altered gene in head and neck squamous cell carcinoma, with mutations occurring in over two-thirds of cases, but the prognostic significance of these mutations remains elusive. In the current ... -
Exercising control when confronted by a (Brownian) spider
(2016)We consider the Brownian “spider,” a construct introduced in Dubins and Schwarz (1988) and in Barlow and Pitman (1989). In this note, the author proves the “spider” bounds by using the dynamic programming strategy of ... -
A factorial analysis of the combined effects of hydrogel fabrication parameters on the in vitro swelling and degradation of oligo(poly(ethylene glycol) fumarate) hydrogels
(2014)In this study, a full factorial approach was used to investigate the effects of poly(ethylene glycol) (PEG) molecular weight (MW; 10,000 vs. 35,000 nominal MW), crosslinker-to-macromer carbon–carbon double bond ratio (DBR; ... -
Factors affecting ambulance utilization for asthma attack treatment: understanding where to target interventions
(2015)Objectives: Asthma is a serious, sometimes fatal condition, in which attacks vary in severity, potentially requiring emergency medical services (EMS) ambulance treatment. A portion of asthma attacks requiring EMS ambulance ... -
Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease
(2016)There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, ... -
A genome-wide trans-ethnic interaction study links theﾠPIGR-FCAMRﾠlocus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic
(2017)Air pollution is a worldwide contributor to cardiovascular disease mortality and morbidity. Traffic-related air pollution is a widespread environmental exposure and is associated with multiple cardiovascular outcomes such ... -
Genomic region detection via Spatial Convex Clustering
(2018)Several modern genomic technologies, such as DNA-Methylation arrays, measure spatially registered probes that number in the hundreds of thousands across multiple chromosomes. The measured probes are by themselves less ... -
Graphical Models via Univariate Exponential Family Distributions
(2015)Undirected graphical models, or Markov networks, are a popular class of statistical models, used in a wide variety of applications. Popular instances of this class include Gaussian graphical models and Ising models. In ... -
Heavy-tailed densities
(2013)The concept of heavy- or long-tailed densities (or distributions) has attracted much well-deserved attention in the literature. A quick search in Google using the keywords long-tailed statistics retrieves almost 12 million ... -
A hierarchical Bayesian model for inference of copy number variants and their association to gene expression
(2014)A number of statistical models have been successfully developed for the analysis of high-throughput data from a single source, but few methods are available for integrating data from different sources. Here we focus on ... -
Hyaluronan turnover and hypoxic brown adipocytic differentiation are co-localized with ossification in calcified human aortic valves
(2012)The calcification process in aortic stenosis has garnered considerable interest but only limited investigation into selected signaling pathways. This study investigated mechanisms related to hypoxia, hyaluronan homeostasis, ... -
Identifying barriers in the malaria control policymaking process in East Africa: insights from stakeholders and a structured literature review
(2015)Background: The complexity of malaria and public health policy responses presents social, financial, cultural, and institutional barriers to policymaking at multiple stages in the policy process. These barriers reduce the ... -
Imaging genetics via sparse canonical correlation analysis
(2013)The collection of brain images from populations of subjects who have been genotyped with genome-wide scans makes it feasible to search for genetic effects on the brain. Even so, multivariate methods are sorely needed that ... -
Impact of hypothermia on implementation of CPAP for neonatal respiratory distress syndrome in a low-resource setting
(2018)Background: Neonatal hypothermia is widely associated with increased risks of morbidity and mortality, but remains a pervasive global problem. No studies have examined the impact of hypothermia on outcomes for preterm ... -
Implications of construction method and spatial scale on measures of the built environment
(2016)Abstract Background Research surrounding the built environment (BE) and health has resulted in inconsistent findings. Experts have identified the need to examine methodological ... -
Individual Differences in the Neural and Cognitive Mechanisms of Single Word Reading
(2018)Written language is a human invention that our brains did not evolve for. Yet, most research has focused on finding a single theory of reading, identifying the common set of cognitive and neural processes shared across ... -
Inferring metabolic networks using the Bayesian adaptive graphical lasso with informative priors
(2013)Metabolic processes are essential for cellular function and survival. We are interested in inferring a metabolic network in activated microglia, a major neuroimmune cell in the brain responsible for the neuroinflammation ...
