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dc.contributor.advisor Nikonowicz, Edward P.
dc.creatorDeJong, Eric Scott
dc.date.accessioned 2009-06-04T08:46:53Z
dc.date.available 2009-06-04T08:46:53Z
dc.date.issued 2000
dc.identifier.urihttps://hdl.handle.net/1911/19484
dc.description.abstract The high-resolution structures of two separate RNA molecules were determined using heteronuclear nuclear magnetic resonance (NMR) spectroscopy. Both RNA molecules, in their respective systems, perform critical functions of regulating gene expression. To explore the dynamic properties of one molecule, an extensive investigation into its fast (<5ns) intra-molecular motions was carried out. The dynamics investigation was performed using a novel application of heteronuclear relaxation measurements from several base and ribose sites within the molecule. The results of this work were then interpreted using various forms of the Lipari and Szabo motional model. The significance of this research is two fold: (1) it provides detailed structures of two RNA molecules and a basis for their roles in protein recognition and binding and (2) augments the structural characterization with direct measurements of fast internal motions using a novel application of heteronuclear NMR relaxation analysis.
dc.format.extent 160 p.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.subjectAnalytical chemistry
Biophysics
dc.title Investigations into nucleic acid structure and dynamics using heteronuclear nuclear magnetic resonance spectroscopic methods
dc.type.genre Thesis
dc.type.material Text
thesis.degree.department Chemistry
thesis.degree.discipline Natural Sciences
thesis.degree.grantor Rice University
thesis.degree.level Doctoral
thesis.degree.name Doctor of Philosophy
dc.identifier.citation DeJong, Eric Scott. "Investigations into nucleic acid structure and dynamics using heteronuclear nuclear magnetic resonance spectroscopic methods." (2000) Diss., Rice University. https://hdl.handle.net/1911/19484.


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