Design of a paracorporeal artificial lung device in an integrative model of the ovine cardiovascular system
Ha, Roy R.
Clark, John W., Jr.
Master of Science thesis
Due to its similar cardiac output and size, the sheep often serves as an important animal model for the study of the human cardiovascular system and for studies of ventricular and pulmonary assist devices. We develop a closed-loop mathematical model of its cardiovascular system and a model of a paracorporeal artificial lung (PAL) device. A distributive model is used to describe the systemic circulation, which contains nonlinear venous pressure-volume characteristics and a consideration of baroreflex. The model can mimic typical hemodynamic data from sheep in both reclining and standing positions. Simulations with the PAL model attached to the whole-body model are performed. We demonstrate the model's ability to accurately describe the hemodynamic effects of PAL attachment and its ability to determine best-fit design parameters to improve device performance.
Engineering, Electronics and Electrical