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dc.contributor.advisor Cox, Steven J.
dc.creatorSchoener, Kyle David
dc.date.accessioned 2009-06-04T08:31:47Z
dc.date.available 2009-06-04T08:31:47Z
dc.date.issued 2004
dc.identifier.urihttps://hdl.handle.net/1911/17726
dc.description.abstract This study introduces a new mathematical approach for determining synaptic location and synaptic conductance from distal voltage recordings. The ability to comprehend how synapses transmit information provides a better understanding of how the brain functions in terms of learning and memory. While other scientists take a more biological approach to solving this problem, we construct a mathematical method that utilizes the cable equation to describe voltage changes in a passive neural fiber and applies the Laplace Transform, moment methods, and numerical approximations to recover the synaptic parameters. Examples demonstrating the recovery of synaptic location and conductance for a single passive fiber are presented. A comparison of our techniques with existing techniques demonstrates our method's overall effectiveness. We conclude that these results can aid in a better understanding of synaptic transmission which is linked to the formation of memories and neurological disorders such as Huntington's, Parkinson's, and Alzheimer's.
dc.format.extent 59 p.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.subjectNeurosciences
Mathematics
Biology
dc.title Recovery of synaptic conductance and location using distal voltage measurements
dc.type.genre Thesis
dc.type.material Text
thesis.degree.department Computational and Applied Mathematics
thesis.degree.discipline Engineering
thesis.degree.grantor Rice University
thesis.degree.level Masters
thesis.degree.name Master of Arts
dc.identifier.citation Schoener, Kyle David. "Recovery of synaptic conductance and location using distal voltage measurements." (2004) Master’s Thesis, Rice University. https://hdl.handle.net/1911/17726.


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