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dc.contributor.advisor Clark, John W., Jr.
dc.creatorAlfrey, Karen D.
dc.date.accessioned 2009-06-04T08:13:17Z
dc.date.available 2009-06-04T08:13:17Z
dc.date.issued 1997
dc.identifier.urihttps://hdl.handle.net/1911/17059
dc.description.abstract The baroreceptor, a stretch-sensitive neuron, senses static and dynamic arterial blood pressure and responds by producing a frequency-modulated train of action potentials. The size and anatomy of baroreceptor nerve endings precludes direct experimental study of the details of baroreceptor behavior; however, studies of output firing frequency in response to arterial pressure changes reveal a highly nonlinear input-output characteristic. While many models of the baroreceptor have been developed, most of these models have failed to provide a comprehensive view of the mechanisms under-lying baroreceptor function. We present a new baroreceptor model which provides a physiologically-based, comprehensive description of all aspects of the system. This model combines a mechanical model of the arterial wall with Hodgkin-Huxley-type models of the transducer and encoder sections of the neuron. The complete model not only mimics a wide range of experimental results, it also provides a means of making predictions about baroreceptor behavior and of examining the mechanisms underlying baroreceptor function.
dc.format.extent 86 p.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.subjectPhysiology
Biomedical engineering
Electronics
Electrical engineering
dc.title A model of the aortic baroreceptor in rat
dc.type.genre Thesis
dc.type.material Text
thesis.degree.department Bioengineering
thesis.degree.discipline Engineering
thesis.degree.grantor Rice University
thesis.degree.level Masters
thesis.degree.name Master of Science
dc.identifier.citation Alfrey, Karen D.. "A model of the aortic baroreceptor in rat." (1997) Master’s Thesis, Rice University. https://hdl.handle.net/1911/17059.


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