Now showing items 21-40 of 1203

    • Single-molecule force measurements of the polymerizing dimeric subunit of von Willebrand factor 

      Wijeratne, Sithara S.; Li, Jingqiang; Yeh, Hui-Chun; Nolasco, Leticia; Zhou, Zhou; Bergeron, Angela; Frey, Eric W.; Moake, Joel L.; Dong, Jing-fei; Kiang, Ching-Hwa (2016)
      Von Willebrand factor (VWF) multimers are large adhesive proteins that are essential to the initiation of hemostatic plugs at sites of vascular injury. The binding of VWF multimers to platelets, as well as VWF proteolysis, ...
    • Comparison study of ring current simulations with and without bubble injections 

      Yang, Jian; Toffoletto, Frank R.; Wolf, Richard A. (2016)
      For many years, stand-alone ring current models have been successfully producing storm time ring current enhancements without specifying explicit localized transient injections along their outer boundaries. However, both ...
    • A window for plate tectonics in terrestrial planet evolution? 

      O’Neill, Craig; Lenardic, Adrian; Weller, Matthew; Moresi, Louis; Quenette, Steve; Zhang, Siqi (2016)
      The tectonic regime of a planet depends critically on the contributions of basal and internal heating to the planetary mantle, and how these evolve through time. We use viscoplastic mantle convection simulations, with ...
    • Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA–DNA pairing 

      Lin, Jiangguo; Countryman, Preston; Chen, Haijiang; Pan, Hai; Fan, Yanlin; Jiang, Yunyun; Kaur, Parminder; Miao, Wang; Gurgel, Gisele; You, Changjiang; Piehler, Jacob; Kad, Neil M.; Riehn, Robert; Opresko, Patricia L.; Smith, Susan; Tao, Yizhi Jane; Wang, Hong (2016)
      Proper chromosome alignment and segregation during mitosis depend on cohesion between sister chromatids. Cohesion is thought to occur through the entrapment of DNA within the tripartite ring (Smc1, Smc3 and Rad21) with ...
    • Structural and Optical Properties of Discrete Dendritic Pt Nanoparticles on Colloidal Au Nanoprisms 

      Leary, Rowan K.; Kumar, Anjli; Straney, Patrick J.; Collins, Sean M.; Yazdi, Sadegh; Dunin-Borkowski, Rafal E.; Midgley, Paul A.; Millstone, Jill E.; Ringe, Emilie (2016)
      Catalytic and optical properties can be coupled by combining different metals into nanoscale architectures where both the shape and composition provide fine-tuning of functionality. Here, discrete, small Pt nanoparticles ...
    • Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB 

      Morgado, Micaela; Sutton, Margie N.; Simmons, Mary; Warren, Curtis R.; Lu, Zhen; Constantinou, Pamela E.; Liu, Jinsong; Francis, Lewis L.W.; Conlan, R. Steven; Bast, Robert C. Jr.; Carson, Daniel D. (2016)
      Transmembrane mucins (TMs) are restricted to the apical surface of normal epithelia. In cancer, TMs not only are over-expressed, but also lose polarized distribution. MUC16/CA125 is a high molecular weight TM carrying the ...
    • The effects of ER morphology on synaptic structure and function inDrosophila melanogaster 

      Summerville, James B.; Faust, Joseph F.; Fan, Ethan; Pendin, Diana; Daga, Andrea; Formella, Joseph; Stern, Michael; McNew, James A. (2016)
      Hereditary spastic paraplegia (HSP) is a set of genetic diseases caused by mutations in one of 72 genes that results in age-dependent corticospinal axon degeneration accompanied by spasticity and paralysis. Two genes ...
    • Stability of the hybrid epithelial/mesenchymal phenotype 

      Jolly, Mohit Kumar; Tripathi, Satyendra C.; Jia, Dongya; Mooney, Steven M.; Celiktas, Muge; Hanash, Samir M.; Mani, Sendurai A.; Pienta, Kenneth J.; Ben-Jacob, Eshel; Levine, Herbert (2016)
      Epithelial-to-Mesenchymal Transition (EMT) and its reverse - Mesenchymal to Epithelial Transition (MET) - are hallmarks of cellular plasticity during embryonic development and cancer metastasis. During EMT, epithelial cells ...
    • Synthesis and Photostability of Unimolecular Submersible Nanomachines: Toward Single-Molecule Tracking in Solution 

      García-López, Víctor; Jeffet, Jonathan; Kuwahara, Shunsuke; Martí, Angel A.; Ebenstein, Yuval; Tour, James M. (2016)
      The synthesis and photophysical properties of a series of photostable unimolecular submersible nanomachines (USNs) are reported as a first step toward the analysis of their trajectories in solution. The USNs have a ...
    • Tumor Budding: The Name is EMT. Partial EMT. 

      Grigore, Alexandru Dan; Jolly, Mohit Kumar; Jia, Dongya; Farach-Carson, Mary C.; Levine, Herbert (2016)
      Tumor budding is a histological phenomenon encountered in various cancers, whereby individual malignant cells and/or small clusters of malignant cells are seen in the tumor stroma. Postulated to be mirror epithelial-mesenchymal ...
    • Collective dynamics of processive cytoskeletal motors 

      McLaughlin, R. Tyler; Diehl, Michael R.; Kolomeisky, Anatoly B. (2016)
      Major cellular processes are supported by various biomolecular motors that usually operate together as teams. We present an overview of the collective dynamics of processive cytokeletal motor proteins based on recent ...
    • New Model for Understanding Mechanisms of Biological Signaling: Direct Transport via Cytonemes 

      Teimouri, Hamid; Kolomeisky, Anatoly B. (2016)
      Biological signaling is a crucial natural process that governs the formation of all multicellular organisms. It relies on efficient and fast transfer of information between different cells and tissues. It has been presumed ...
    • Carbon nanotube fiber terahertz polarizer 

      Zubair, Ahmed; Tsentalovich, Dmitri E.; Young, Colin C.; Heimbeck, Martin S.; Everitt, Henry O.; Pasquali, Matteo; Kono, Junichiro (2016)
      Conventional, commercially available terahertz (THz) polarizers are made of uniformly and precisely spaced metallic wires. They are fragile and expensive, with performance characteristics highly reliant on wire diameters ...
    • Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research 

      King, Kevin R.; Grazette, Luanda P.; Paltoo, Dina N.; McDevitt, John T.; Sia, Samuel K.; Barrett, Paddy M.; Apple, Fred S.; Gurbel, Paul A.; Weissleder, Ralph; Leeds, Hilary; Iturriaga, Erin J.; Rao, Anupama K.; Adhikari, Bishow; Desvigne-Nickens, Patrice; Galis, Zorina S.; Libby, Peter (2016)
      Point-of-care technologies (POC or POCT) are enabling innovative cardiovascular diagnostics that promise to improve patient care across diverse clinical settings. The National Heart, Lung, and Blood Institute convened a ...
    • Chiral and Achiral Nanodumbbell Dimers: The Effect of Geometry on Plasmonic Properties 

      Smith, Kyle W.; Zhao, Hangqi; Zhang, Hui; Sánchez -Iglesias, Ana; Grzelczak, Marek; Wang, Yumin; Chang, Wei-Shun; Nordlander, Peter; Liz-Marzán, Luis; Link, Stephan (2016)
      Metal nanoparticles with a dumbbell-like geometry have plasmonic properties similar to those of their nanorod counterparts, but the unique steric constraints induced by their enlarged tips result in distinct geometries ...
    • FlowCal: A User-Friendly, Open Source Software Tool for Automatically Converting Flow Cytometry Data from Arbitrary to Calibrated Units 

      Castillo-Hair, Sebastian M.; Sexton, John T.; Landry, Brian P.; Olson, Evan J.; Igoshin, Oleg A.; Tabor, Jeffrey J. (2016)
      Flow cytometry is widely used to measure gene expression and other molecular biological processes with single cell resolution via fluorescent probes. Flow cytometers output data in arbitrary units (a.u.) that vary with the ...
    • Mode of Action of Antimicrobial Peptides on E. coli Spheroplasts 

      Sun, Yen; Sun, Tzu-Lin; Huang, Huey W. (2016)
      We investigated the phenomena of antimicrobial peptides (AMPs) directly attacking the cytoplasmic membranes of Escherichia coli spheroplasts. We developed a procedure for fluorescence recovery after photobleaching to examine ...
    • Turning On and Off Photoinduced Electron Transfer in Fluorescent Proteins by π-Stacking, Halide Binding, and Tyr145 Mutations 

      Bogdanov, Alexey M.; Acharya, Atanu; Titelmayer, Anastasia V.; Mamontova, Anastasia V.; Bravaya, Ksenia B.; Kolomeisky, Anatoly B.; Lukyanov, Konstantin A.; Krylov, Anna I. (2016)
      Photoinduced electron transfer in fluorescent proteins from the GFP family can be regarded either as an asset facilitating new applications or as a nuisance leading to the loss of optical output. Photooxidation commonly ...
    • MUC1 stimulates EGFR expression and function in endometrial cancer 

      Engel, Brian J.; Bowser, Jessica L.; Broaddus, Russell R.; Carson, Daniel D. (2016)
      The current standard of care for endometrial cancer patients involves hysterectomy with adjuvant radiation and chemotherapy, with no effective treatment for advanced and metastatic disease. MUC1 is a large, heavily ...
    • Quantum mechanical effects in plasmonic structures with subnanometre gaps 

      Zhu, Wenqi; Esteban, Ruben; Borisov, Andrei G.; Baumberg, Jeremy J.; Nordlander, Peter; Lezec, Henri J.; Aizpurua, Javier; Crozier, Kenneth B. (2016)
      Metallic structures with nanogap features have proven highly effective as building blocks for plasmonic systems, as they can provide a wide tuning range of operating frequencies and large near-field enhancements. Recent ...