Synthetic studies toward the total synthesis of (+)-anthramycin total syntheses of (+)-neothramycins A and B
Doctor of Philosophy
Through the serendipitous discovery of a palladium catalyzed conversion of ethylthiol esters to their corresponding aldehydes, the pyrrolo (1,4) benzodiazepine systems found in (+)-anthramycin 1a* and (+)-neothramycins A 2a and B 2b have been constructed from the diethylthiol esters 3 and 4 respectively. A key intermediate 5 for the total synthesis of (+)-anthramycin and a facile route to (+)-neothramycins A and B are thus provided. ftn*Please refer to dissertation for diagrams.
Organic chemistry; Pharmaceutical chemistry