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dc.contributor.advisor Fukuyama, Tohru
dc.creatorAjeck-Carman, Karen Lynn
dc.date.accessioned 2009-06-04T00:21:36Z
dc.date.available 2009-06-04T00:21:36Z
dc.date.issued 1988
dc.identifier.citation Ajeck-Carman, Karen Lynn. "Synthetic studies towards the total synthesis of the saframycins." (1988) Diss., Rice University. https://hdl.handle.net/1911/16123.
dc.identifier.urihttps://hdl.handle.net/1911/16123
dc.description.abstract A key improvement to the original saframycin B synthesis involves efficient sequential piperazinedione condensations to yield a basic saframycin skeleton from which all congeners might be made. Approaches toward the total synthesis of saframycin A result in formation of two advanced intermediates. The first, a pentacyclic diphenol nitrile with at least four out of five stereocenters established, is synthesized via a multistep scheme which involves a Pictet-Spengler type phenolic cyclization. The second advanced intermediate is produced via a route which involves cleavage of an imidazolidine ring with concomitant introduction of cyanide. An isomer of saframycin A is synthesized using this approach.
dc.format.extent 227 p.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.subjectOrganic chemistry
dc.title Synthetic studies towards the total synthesis of the saframycins
dc.type Thesis
dc.type.material Text
thesis.degree.department Chemistry
thesis.degree.discipline Natural Sciences
thesis.degree.grantor Rice University
thesis.degree.level Doctoral
thesis.degree.name Doctor of Philosophy
dc.identifier.callno Thesis Chem. 1988 Ajeck


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