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dc.creatorMUELLER, JAY VINCENT
dc.date.accessioned 2007-05-09T19:36:09Z
dc.date.available 2007-05-09T19:36:09Z
dc.date.issued 1984
dc.identifier.urihttp://hdl.handle.net/1911/15846
dc.description.abstract The biosynthesis of the antibiotic elaiomycin (1), produced by Streptomyces gelaticus, has been investigated. Precursor incorporation studies using (('13)C)- and {('3)H,('14)C}-labeled forms of serine have shown that carbons 2-4 of elaiomycin are derived from serine, with the hydroxymethyl carbon of serine being incorporated into C-4 of elaiomycin. An administration of (methyl-('13)C)-methionine has proven the methyl carbon of methionine to be the source of the O-methyl carbon of elaiomycin. (('13)C)- and {('14)C}-labeled precursor incorporation experiments indicate the novel introduction of C-2 of acetate into C-1 of elaiomycin. The administration of precursors labeled with contiguous ('13)C and ('15)N atoms has shown the oxygen-bearing nitrogen atom in elaiomycin to be derived from n-octylamine and the other nitrogen atom to be derived from serine.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.subjectOrganic chemistry
dc.title INVESTIGATIONS OF THE BIOSYNTHESIS OF ELAIOMYCIN
dc.type.genre Thesis
dc.type.material Text
thesis.degree.department Chemistry
thesis.degree.discipline Natural Sciences
thesis.degree.grantor Rice University
thesis.degree.level Doctoral
thesis.degree.name Doctor of Philosophy


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