Show simple item record

dc.contributor.advisor Glantz, Raymon M.
dc.creatorHillman, Timothy Mark
dc.date.accessioned 2009-06-03T23:59:38Z
dc.date.available 2009-06-03T23:59:38Z
dc.date.issued 1995
dc.identifier.urihttps://hdl.handle.net/1911/13960
dc.description.abstract Using immunocytochemical and electrophysiological methods, the effects of mutations in the structural gene for a calcium activated potassium channel, slowpoke (slo), in Drosophila melanogaster were studied. Anti-horseradish peroxidase was used to visualize the branching of the nerves innervating the body wall muscles. No differences are observed between slo and normal larvae. Defects in synaptic transmission at the neuromuscular junction were analyzed electrophysiologically. slo mutants show significant reductions in transmitter release. Also, slo mutations paired with hyperexcitable mutants (Shaker, ether a go go) and/or pharmacological agents (4-aminopyridine) significantly decrease the high amounts of transmitter release normally observed in these situations. Significant reductions in transmitter release caused by the slo mutation are only observed at low external calcium concentrations. This decrease in transmitter release may be due to reduced neuronal excitability conferred by the slo mutation.
dc.format.extent 43 p.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.subjectPhysiology
Cell biology
Neurosciences
dc.title Decreased transmitter release conferred by a mutation in the slowpoke-encoded calcium-dependent potassium channel gene at the Drosophila neuromuscular junction
dc.type.genre Thesis
dc.type.material Text
thesis.degree.department Biology
thesis.degree.discipline Natural Sciences
thesis.degree.grantor Rice University
thesis.degree.level Masters
thesis.degree.name Master of Science
dc.identifier.citation Hillman, Timothy Mark. "Decreased transmitter release conferred by a mutation in the slowpoke-encoded calcium-dependent potassium channel gene at the Drosophila neuromuscular junction." (1995) Master’s Thesis, Rice University. https://hdl.handle.net/1911/13960.


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record