Mathematical analysis of the relationship between intra- and extracellular potentials from His bundle in rabbit heart
Clark, John W., Jr.
Master of Science
This study is concerned with the relationship between the intra- and extracellular potentials associated with the His bundle of the rabbit heart. A Hodgkin-Huxley type model of the Purkinje cell is developed and subsequently used to simulate conduction in a cable-model of the His bundle. The simulation results indicate that the field potential waveform can be decomposed and analyzed in terms of the component currents of the His bundle model. A field-theoretic model is also developed to analyze the relationship between the intra- and extracellular potentials of the His bundle. This relationship is treated as an equivalent filtering problem, wherein the extracellular field potential is predicted by specifying the action potential waveform and the equivalent filter characteristic.