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Effect of laminar shear stress on gene regulation, protein synthesis, and protein secretion by cultured human endothelial cells
To test the hypothesis that wall shear stress generated by blood flow may regulate endothelial cell expression of blood clot dissolving proteins or vasoactive proteins, an in vitro perfusion system was used to expose human ...
Establishment, cultivation and optimization of hairy roots of Catharanthus roseus for the synthesis of indole alkaloids
"Hairy" roots hold the potential for economically feasible biotechnological routes to the controlled biosynthesis of complex, plant-derived, 'natural' molecules. A novel transgenic root system of the tropical plant ...
A study of the fluid mechanics and the cultivation of mammalian cells in a magnetically stabilized fluidized bed bioreactor
The culture of anchorage dependent mammalian cells on microcarrier offers an attractive avenue for achieving high productivity of therapeutic and diagnostic proteins in bioreactors. Reducing production costs require high ...