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Mapping tumor metabolism: from personalized multiobjective metabolic flux analysis to intercellular metabolite transport via exosomes
Departure from healthy and tightly-regulated metabolism is an emerging hallmark of cancer that facilitates tumorigenic characteristics of uncontrolled proliferation, metastasis, and resistance to chemotherapy. Our aim is ...
Tumor Microenvironment Derived Exosomes Pleiotropically Modulate Cancer Cell Metabolism
Exosomes are extracellular vesicles responsible for efficient cell-to-cell communications. We intended to investigate the role of tumor microenvironment (TME) derived exosomes in regulating cancer cell metabolism. We found ...