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Engineering Escherichia coli for the production of polyketide-based platform chemicals
The current chemical industry produces a diverse array of industrial chemicals from a handful of highly reduced byproducts (termed "platform chemicals") derived from oil refining. However, petroleum is a non-renewable ...
Novel approaches for the production of fuels and chemicals in Escherichia coli
Volatility of oil prices along with major concerns about climate change, oil supply security and depleting reserves have sparked renewed interest in the production of biofuels and biochemicals. While the carbohydrate portion ...
Improved Understanding of Apoptosis and Metabolism in Chinese Hamster Ovary Cell Culture
Mammalian cell culture has gained importance in biotechnology for the development of therapeutic and diagnostic agents. Among them, Chinese hamster ovary (CHO) cells are regarded as the mammalian cell "workhorse". The use ...
Kinetic and statistical approaches in metabolic networks
The work in the current thesis is focused on the metabolomics field. In general, studies in this area concentrate on obtaining information concerning the metabolites found in a biological sample. Acquiring and analyzing ...