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Engineering Escherichia coli for the production of polyketide-based platform chemicals
The current chemical industry produces a diverse array of industrial chemicals from a handful of highly reduced byproducts (termed "platform chemicals") derived from oil refining. However, petroleum is a non-renewable ...
Improved Understanding of Apoptosis and Metabolism in Chinese Hamster Ovary Cell Culture
Mammalian cell culture has gained importance in biotechnology for the development of therapeutic and diagnostic agents. Among them, Chinese hamster ovary (CHO) cells are regarded as the mammalian cell "workhorse". The use ...
Modeling a Reversed β-oxidation Cycle Into the Genome Scale Model of Zymomonas mobilis
This study proposes simulations which present optimized methods for producing fatty acids, fatty alcohols and alkanes using Zymomonas mobilis bacterium by the energy efficient β-oxidation reversal pathway, an eco-friendly ...
Kinetic and statistical approaches in metabolic networks
The work in the current thesis is focused on the metabolomics field. In general, studies in this area concentrate on obtaining information concerning the metabolites found in a biological sample. Acquiring and analyzing ...