Now showing items 1-6 of 6
Development and Evaluation of Approaches for Quantitative Optical Molecular Imaging of Neoplasia
This thesis develops and evaluates three approaches for quantitative molecularly-targeted optical imaging of neoplasia. The first approach focuses on widefield imaging of biomarkers near the tissue surface for early detection ...
Modulating Gold Nanoparticle in vivo Delivery for Photothermal Therapy Applications Using a T Cell Delivery System
This thesis reports new gold nanoparticle-based methods to treat chemotherapy-resistant and metastatic tumors that frequently evade conventional cancer therapies. Gold nanoparticles represent an innovative generation of ...
Tailoring vessel morphology in vivo
Tissue engineering is a rapidly growing field which seeks to provide alternatives to organ transplantation in order to address the increasing need for transplantable tissues. One huge hurdle in this effort is the provision ...
Strategies for the Mitigation of Oxysterol-Induced Cytotoxicity
Chronic exposure to some oxysterols might contribute to deterioration of human or environmental health. Oxysterols are both biomarkers of oxidative stress as well as mediators of its damage, and play a central role in many ...
Novel Methods for Reducing Breast Dose During Computed Tomography Scans
Pediatric female and young adult female patients who undergo computed tomography (CT) scanning may be at higher risk for developing radiation-induced breast cancer later in life. Thus, the purpose of this thesis was to ...
Harnessing Inflammatory Signaling to Promote Bone Regeneration and Mitigate Joint Damage
Inflammatory processes are infamous for their destructive effects on tissues and joints in a variety of diseases. Within the body, inflammation is a highly regulated biological response whose purpose is to promote tissue ...