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Nitric Oxide: The Missing Link in Omentum-Induced Metabolic reprogramming of ovarian cancers
A novel metabolic regulatory mechanism of ovarian cancer by omentum adipose-derived stroma cells (O-ASCs) has been discovered. O-ASCs induce survival, migration, and chemoresistance of ovarian cancer cells. However, the ...
Mapping tumor metabolism: from personalized multiobjective metabolic flux analysis to intercellular metabolite transport via exosomes
Departure from healthy and tightly-regulated metabolism is an emerging hallmark of cancer that facilitates tumorigenic characteristics of uncontrolled proliferation, metastasis, and resistance to chemotherapy. Our aim is ...
Glutaminolysis: A Hallmark of Cancer Metabolism
The goals of these projects are to study the critical role of glutamine (Gln) in ovarian cancer growth, metastasis, drug resistance and sources of glutamine in tumor microenvironment. 1): Gln‐addicted cancer cells are ...
Tumor Microenvironment Derived Exosomes Pleiotropically Modulate Cancer Cell Metabolism
Exosomes are extracellular vesicles responsible for efficient cell-to-cell communications. We intended to investigate the role of tumor microenvironment (TME) derived exosomes in regulating cancer cell metabolism. We found ...