Now showing items 1-20 of 252

• #### 2,4,6-trinitrotoluene reduction by hydrogenase in Clostridium acetobutylicum ﻿

(2003)
Unique genetic modifications to C. acetobutylicum altered the level of hydrogenase expression, allowing study of the resulting effects on the 2,4,6-trinitrotoluene (TNT) reduction rates to be possible. A strain designed ...
• #### 5alpha-cholest-8(14)-en-3beta-ol-15-one. Studies on its metabolism in cultured cells and male baboons. (Volumes I and II) ﻿

(1989)
5$\alpha$-Cholest-8(14)-en-3$\beta$-ol-15-one is a potent inhibitor of cholesterol biosynthesis which has been found to have significant hypocholesterolemic action upon oral administration to rodents and nonhuman primates. ...
• #### A comparative study of the membrane-active beta-sheet peptide protegrin with the alpha-helical peptide alamethicin ﻿

(1999)
The interactions of the membrane-active peptides alamethicin and protegrin with lipid bilayers are studied. The influence of the bilayer composition on the orientation transition of alamethicin is studied using oriented ...
• #### A continuous kinetic assay for RecA-mediated DNA strand exchange using DNA-based flourescent signal ﻿

(2000)
A continuous kinetic assay for RecA-mediated DNA strand exchange using a DNA-based fluorescent signal has been successfully developed and employed. 2-Aminopurine deoxyribonucleoside phosphoradmite was synthesized and ...
• #### A flexible lattice model to study protein folding ﻿

(1996)
The biological activity of protein molecules is central to life. It has been known for decades that this biological activity is dependent on the protein molecule achieving a particular geometric conformation. Simple lattice ...
• #### A library approach to single site and combinatorial residue contributions to dimerization of BNIP3-like transmembrane domains ﻿

(2012)
A poly-leucine transmembrane domain library was randomized at positions corresponding to contact surfaces for a right-handed crossing of two helices to determine the significance of small residues, GxxxG motifs, and hydrogen ...
• #### A lov Story: A role for jim lovell in Drosophila neural development and fertility. ﻿

(2011)
A forward genetic screen looking for altered gravity response identified the gene jim lovell (lov). This gene is related to the gene fruitless, which specifies male courtship ii behavior in Drosophila. Like fruitless, ...
• #### A structure-function characterization of the ER membrane protein atlastin ﻿

(2012)
The biogenesis and maintenance of the entire endomembrane system is dependent upon membrane fusion proteins. Mounting evidence indicates that the integral membrane GTPase Atlastin is a membrane fusion protein involved in ...

(1969)
• #### Ab initio methods for protein structure prediction ﻿

(2010)
Recent breakthroughs in DNA and protein sequencing have unlocked many secrets of molecular biology. A complete understanding of gene function, however, requires a protein structure in addition to its sequence. Modern protein ...
• #### Additional insights into the structure and function of adenosine deaminase ﻿

(1998)
Adenosine deaminase is a key enzyme in purine catabolism. The elucidation of the crystal structure and recent analysis of site-directed mutants have provided details on the structure and function of the enzyme. The studies ...
• #### Alkyl isocyanides as transition state analogs for ligand entry and exit in globins ﻿

(2008)
There are two competing models for ligand entry and exit in globins. In the histidine gate model, a channel from the heme iron to the solvent opens by the outward rotation of the His(E7) side chain (7 th residue of the ...
• #### Analysis of physiological roles of Drosophila calmodulin through in vivo genetic and in vitro structure/function studies ﻿

(2003)
Calmodulin (CaM), a small protein found in all eukaryotes examined, is a major component of Ca2+ signaling pathways and functions as a Ca2+ signal sensor and transducer. A wide variety of targets are regulated by CaM, ...
• #### Apoglobin stability and ligand movements in mammalian myoglobins ﻿

(1998)
The design of recombinant globins as oxygen storage and delivery pharmaceuticals must address two key protein engineering problems, one dealing with the improvement of apoprotein stability and the other with the structural ...
• #### Application of metabolic and biochemical engineering techniques for the enhancement of recombinant protein production in Escherichia coli ﻿

(1995)
This study focuses on the application of metabolic engineering techniques to diminish acetate excretion, as a means to enhance recombinant protein productivities. The recombinant model system is based on the formation of ...

(1970)
• #### ASPECTS OF ELECTRON TRANSFER IN XANTHINE OXIDASE ﻿

(1982)
The characteristics of the oxidation reaction and of the thermodynamics of electron transfer in xanthine oxidase were analyzed by stopped flow spectrophotometry and room temperature potentiometric titrations. Product ...
• #### Assessing the relationship between soil reduction and methane emission in Texas rice fields ﻿

(1995)
Reduction processes and methane emissions have been observed in six rice fields along a sand-clay-silt gradient for one growing season. Variations in reduction processes occurred by depth and upon field draining, as well ...
• #### Bioavailability of polycyclic aromatic hydrocarbons as sediment-associated, desorption-resistant contaminants ﻿

(2000)
This study investigated the bioavailability of sediment-sorbed polycyclic aromatic hydrocarbons (PAHs), specifically naphthalene, phenanthrene and fluoranthene to a mixed microbial culture after extensive step desorption. ...
• #### BIOCHEMICAL AND BIOPHYSICAL STUDIES OF THE LACTOSE REPRESSOR AND OPERATOR DNA ﻿

(1983)
Lactose repressor from Escherichia coli regulates the expression of the lac operon. The protein binds specifically to the operator region and nonspecifically to the rest of genome. The repression is released upon addition ...