Now showing items 1-2 of 2

    • Algorithms for Scalable Structural Analysis of Class I Peptide-MHC Systems 

      Abella, Jayvee Ralph (2020-04-22)
      Peptide-MHC (pMHC) complexes are central components of the immune system, and understanding the mechanism behind stable pMHC binding will aid the development of immunotherapies. Stable pMHC binding can be assessed through an analysis of structure, which contain information on the atomic interactions present between peptide and MHC. However, a large-scale ...
    • Scaling Up Robotics-Inspired Conformational Sampling Algorithms 

      Abella, Jayvee Ralph (2016-12-01)
      The ability to efficiently sample a protein’s conformational space allows one to understand how a protein may interact with different partners. Algorithms from sampling-based robot motion planning have been used for conformational sampling of small-sized systems. These algorithms keep track of “coverage” in conformational space based on what has been ...