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dc.contributor.authorTeimouri, Hamid
Mukherjee, Rupsha
Kolomeisky, Anatoly B.
dc.date.accessioned 2020-11-11T20:20:28Z
dc.date.available 2020-11-11T20:20:28Z
dc.date.issued 2020
dc.identifier.citation Teimouri, Hamid, Mukherjee, Rupsha and Kolomeisky, Anatoly B.. "Stochastic Mechanisms of Cell-Size Regulation in Bacteria." The Journal of Physical Chemistry Letters, 11, no. 20 (2020) American Chemical Society: 8777-8782. https://doi.org/10.1021/acs.jpclett.0c02627.
dc.identifier.urihttps://hdl.handle.net/1911/109548
dc.description.abstract How bacteria are able to maintain their sizes remains an open question. It is believed that cells have narrow distributions of sizes as a consequence of a homeostasis that allows bacteria to function at the optimal conditions. Several phenomenological approaches to explain these observations have been presented, but the microscopic origins of the cell-size regulation are still not understood. Here, we propose a new stochastic approach to investigate the molecular mechanisms of maintaining the cell sizes in bacteria. It is argued that the cell-size regulation is a result of coupling of two stochastic processes, cell growth and division, which eliminates the need for introducing the thresholds. Dynamic properties of the system are explicitly evaluated, and it is shown that the model is consistent with the experimentally supported adder principle of the cell-size regulation. In addition, theoretical predictions agree with experimental observations on E. coli bacteria. Theoretical analysis clarifies some important features of bacterial cell growth.
dc.language.iso eng
dc.publisher American Chemical Society
dc.rights This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.
dc.title Stochastic Mechanisms of Cell-Size Regulation in Bacteria
dc.type Journal article
dc.citation.journalTitle The Journal of Physical Chemistry Letters
dc.contributor.org Center for Theoretical Biological Physics
dc.citation.volumeNumber 11
dc.citation.issueNumber 20
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1021/acs.jpclett.0c02627
dc.type.publication post-print
dc.citation.firstpage 8777
dc.citation.lastpage 8782


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