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dc.contributor.authorMallory, Xian F.
Edrisi, Mohammadamin
Navin, Nicholas
Nakhleh, Luay
dc.date.accessioned 2020-11-03T19:41:53Z
dc.date.available 2020-11-03T19:41:53Z
dc.date.issued 2020
dc.identifier.citation Mallory, Xian F., Edrisi, Mohammadamin, Navin, Nicholas, et al.. "Methods for copy number aberration detection from single-cell DNA-sequencing data." Genome Biology, 21, (2020) Springer Nature: https://doi.org/10.1186/s13059-020-02119-8.
dc.identifier.urihttps://hdl.handle.net/1911/109487
dc.description.abstract Copy number aberrations (CNAs), which are pathogenic copy number variations (CNVs), play an important role in the initiation and progression of cancer. Single-cell DNA-sequencing (scDNAseq) technologies produce data that is ideal for inferring CNAs. In this review, we review eight methods that have been developed for detecting CNAs in scDNAseq data, and categorize them according to the steps of a seven-step pipeline that they employ. Furthermore, we review models and methods for evolutionary analyses of CNAs from scDNAseq data and highlight advances and future research directions for computational methods for CNA detection from scDNAseq data.
dc.language.iso eng
dc.publisher Springer Nature
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.title Methods for copy number aberration detection from single-cell DNA-sequencing data
dc.type Journal article
dc.citation.journalTitle Genome Biology
dc.citation.volumeNumber 21
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1186/s13059-020-02119-8
dc.type.publication publisher version
dc.citation.articleNumber 208


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