Show simple item record

dc.contributor.authorAsthana, Vishwaratn
Stern, Brett S.
Tang, Yuqi
Bugga, Pallavi
Li, Ang
Ferguson, Adam
Asthana, Anantratn
Bao, Gang
Drezek, Rebekah A.
dc.date.accessioned 2020-11-03T19:41:52Z
dc.date.available 2020-11-03T19:41:52Z
dc.date.issued 2020
dc.identifier.citation Asthana, Vishwaratn, Stern, Brett S., Tang, Yuqi, et al.. "Development of a Novel Class of Self-Assembling dsRNA Cancer Therapeutics: A Proof-of-Concept Investigation." Molecular Therapy: Oncolytics, 18, (2020) Cell Press: 419-431. https://doi.org/10.1016/j.omto.2020.07.013.
dc.identifier.urihttps://hdl.handle.net/1911/109484
dc.description.abstract Cancer has proven to be an extremely difficult challenge to treat. Several fundamental issues currently underlie cancer treatment, including differentiating self from nonself, functional coupling of the recognition and therapeutic components of various therapies, and the propensity of cancerous cells to develop resistance to common treatment modalities via evolutionary pressure. Given these limitations, there is an increasing need to develop an all-encompassing therapeutic that can uniquely target malignant cells, decouple recognition from treatment, and overcome evolutionarily driven cancer resistance. We describe herein a new class of programmable self-assembling double-stranded RNA (dsRNA)-based cancer therapeutics that uniquely targets aberrant genetic sequences and in a functionally decoupled manner, undergoes oncogenic RNA-activated displacement (ORAD), initiating a therapeutic cascade that induces apoptosis and immune activation. As a proof of concept, we show that RNA strands targeting the EWS/Fli1 fusion gene in Ewing sarcoma cells that are end blocked with phosphorothioate bonds and additionally sealed with a 2′-deoxyuridine (2′-U)-modified DNA protector can be used to induce specific and potent killing of cells containing the target oncogenic sequence but not wild type.
dc.language.iso eng
dc.publisher Cell Press
dc.rights This is an open access article under the CC BY-NC-ND license
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Development of a Novel Class of Self-Assembling dsRNA Cancer Therapeutics: A Proof-of-Concept Investigation
dc.type Journal article
dc.citation.journalTitle Molecular Therapy: Oncolytics
dc.citation.volumeNumber 18
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1016/j.omto.2020.07.013
dc.type.publication publisher version
dc.citation.firstpage 419
dc.citation.lastpage 431


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record