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dc.contributor.authorKim, Jangwon
Bae, Jin H.
Baym, Michael
Zhang, David Yu
dc.date.accessioned 2020-10-21T18:16:22Z
dc.date.available 2020-10-21T18:16:22Z
dc.date.issued 2020
dc.identifier.citation Kim, Jangwon, Bae, Jin H., Baym, Michael, et al.. "Metastable hybridization-based DNA information storage to allow rapid and permanent erasure." Nature Communications, 11, (2020) Springer Nature: https://doi.org/10.1038/s41467-020-18842-6.
dc.identifier.urihttps://hdl.handle.net/1911/109439
dc.description.abstract The potential of DNA as an information storage medium is rapidly growing due to advances in DNA synthesis and sequencing. However, the chemical stability of DNA challenges the complete erasure of information encoded in DNA sequences. Here, we encode information in a DNA information solution, a mixture of true message- and false message-encoded oligonucleotides, and enables rapid and permanent erasure of information. True messages are differentiated by their hybridization to a "truth marker” oligonucleotide, and only true messages can be read; binding of the truth marker can be effectively randomized even with a brief exposure to the elevated temperature. We show 8 separate bitmap images can be stably encoded and read after storage at 25 °C for 65 days with an average of over 99% correct information recall, which extrapolates to a half-life of over 15 years at 25 °C. Heating to 95 °C for 5 minutes, however, permanently erases the message.
dc.language.iso eng
dc.publisher Springer Nature
dc.rights This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.title Metastable hybridization-based DNA information storage to allow rapid and permanent erasure
dc.type Journal article
dc.citation.journalTitle Nature Communications
dc.contributor.org Systems, Synthetic, and Physical Biology
dc.contributor.org Center for Theoretical Biological Physics
dc.citation.volumeNumber 11
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1038/s41467-020-18842-6
dc.type.publication publisher version
dc.citation.articleNumber 5008


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