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dc.contributor.authorThomas, Chris S.
Braun, Doug R.
Olmos, Jose Luis
Rajski, Scott R.
Phillips, George N.
Andes, David N.
Bugni, Tim S.
dc.date.accessioned 2020-10-16T18:17:13Z
dc.date.available 2020-10-16T18:17:13Z
dc.date.issued 2020
dc.identifier.citation Thomas, Chris S., Braun, Doug R., Olmos, Jose Luis, et al.. "Pyridine-2,6-Dithiocarboxylic Acid and Its Metal Complexes: New Inhibitors of New Delhi Metallo -Lactamase-1." Marine Drugs, 18, no. 6 (2020) MDPI: https://doi.org/10.3390/md18060295.
dc.identifier.urihttps://hdl.handle.net/1911/109422
dc.description.abstract Carbapenem-resistant Enterobacteriaceae continue to threaten human health worldwide with few effective treatment options. New Delhi metallo--lactamase (NDM) enzymes are a contributing element that drive resistance to many -lactam- and carbapenem-based antimicrobials. Many NDM inhibitors are known, yet none are clinically viable. In this study, we present and characterize a new class of NDM-1 inhibitors based on a pyridine-2,6-dithiocarboxylic acid metal complex scaffold. These complexes display varied and unique activity profiles against NDM-1 in kinetic assays and serve to increase the effectiveness of meropenem, an established antibacterial, in assays using clinical Enterobacteriaceae isolates.
dc.language.iso eng
dc.publisher MDPI
dc.rights This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.title Pyridine-2,6-Dithiocarboxylic Acid and Its Metal Complexes: New Inhibitors of New Delhi Metallo -Lactamase-1
dc.type Journal article
dc.citation.journalTitle Marine Drugs
dc.subject.keywordNDM-1 inhibitors
marine-derived Streptomyces sp.
carbapenem-resistant Enterobacteriaceae
metal chelators
dc.citation.volumeNumber 18
dc.citation.issueNumber 6
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.3390/md18060295
dc.type.publication publisher version
dc.citation.articleNumber 295


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