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dc.contributor.authorTang, Juan
Wang, Lushun
Loredo, Axel
Cole, Carson
Xiao, Han
dc.date.accessioned 2020-08-14T20:13:37Z
dc.date.available 2020-08-14T20:13:37Z
dc.date.issued 2020
dc.identifier.citation Tang, Juan, Wang, Lushun, Loredo, Axel, et al.. "Single-atom replacement as a general approach towards visible-light/near-infrared heavy-atom-free photosensitizers for photodynamic therapy." Chemical Science, 11, no. 26 (2020) Royal Society of Chemistry: 6701-6708. https://doi.org/10.1039/D0SC02286A.
dc.identifier.urihttps://hdl.handle.net/1911/109219
dc.description.abstract Photodynamic therapy has become an emerging strategy for the treatment of cancer. This technology relies on the development of photosensitizers (PSs) that convert molecular oxygen to cytotoxic reactive oxygen species upon exposure to light. In this study, we have developed a facile and general strategy for obtaining visible light/near-infrared-absorbing PSs by performing a simple sulfur-for-oxygen replacement within existing fluorophores. Thionation of carbonyl groups within existing fluorophore cores leads to an improvement of the singlet oxygen quantum yield and molar absorption coefficient at longer wavelengths (deep to 600–800 nm). Additionally, these thio-based PSs lack dark cytotoxicity but exhibit significant phototoxicity against monolayer cancer cells and 3D multicellular tumor spheroids with IC50 in the micromolar range. To achieve tumor-specific delivery, we have conjugated these thio-based PSs to an antibody and demonstrated their tumor-specific therapeutic activity.
dc.language.iso eng
dc.publisher Royal Society of Chemistry
dc.rights This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/
dc.title Single-atom replacement as a general approach towards visible-light/near-infrared heavy-atom-free photosensitizers for photodynamic therapy
dc.type Journal article
dc.citation.journalTitle Chemical Science
dc.citation.volumeNumber 11
dc.citation.issueNumber 26
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1039/D0SC02286A
dc.type.publication publisher version
dc.citation.firstpage 6701
dc.citation.lastpage 6708


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