Now showing items 1-20 of 73

    • A predictive model of the temperature-dependent inactivation of coronaviruses 

      Yap, Te Faye; Liu, Zhen; Shveda, Rachel A.; Preston, Daniel J. (2020)
      The COVID-19 pandemic has stressed healthcare systems and supply lines, forcing medical doctors to risk infection by decontaminating and reusing single-use personal protective equipment. The uncertain future of the pandemic is compounded by limited data on the ability of the responsible virus, SARS-CoV-2, to survive across various climates, preventing ...
    • Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2 

      Azouz, Nurit P.; Klingler, Andrea M.; Callahan, Victoria; Akhrymuk, Ivan V.; Elez, Katarina; (2021)
      Background: Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversial. Transmembrane serine protease 2 (TMPRSS2) is regarded as one of the main proteases implicated in the coronavirus S protein ...
    • Already vulnerable neighborhoods are hardest hit by COVID-19 job losses 

      An interactive dashboard created by the Kinder Institute’s Houston Community Data Connections shows job-loss estimates in each Harris County community. The numbers can be further broken down by industry and neighborhood. Many of the areas impacted most by the economic downturn are home to low-income renters, the working poor and single-parent households.
    • Association of anticoagulation dose and survival in hospitalized COVID‐19 patients: A retrospective propensity score‐weighted analysis 

      Ionescu, Filip; Jaiyesimi, Ishmael; Petrescu, Ioana; Lawler, Patrick R.; Castillo, Edward; (2020)
      Background: Hypercoagulability may contribute to COVID‐19 pathogenicity. The role of anticoagulation (AC) at therapeutic (tAC) or prophylactic doses (pAC) is unclear. Objectives: We evaluated the impact on survival of different AC doses in COVID‐19 patients. Methods: Retrospective, multi‐center cohort study of consecutive COVID‐19 patients hospitalized ...
    • Birthing Between the “Traditional” and the “Modern”: DāĪ Practices and Childbearing Women’s Choices During COVID-19 in Pakistan 

      Ali, Inayat; Sadique, Salma; Ali, Shahbaz; Davis-Floyd, Robbie (2021)
      Pregnancy and birth are biological phenomena that carry heavy cultural overlays, and pregnant and birthing women need care and attention during both ordinary and extraordinary times. Most Pakistani pregnant women now go to doctors and hospitals for their perinatal care. Yet traditional community midwives, called DāĪ in the singular and Dāyūn in the ...
    • Blocked by Gender: Disparities in COVID19 infection detection in Tamil Nadu, India 

      Samanta, Tannistha; Gopalan, Kaushik; Devi, Tanmay (2022)
      Globally, a gender gap in COVID-19 has been noted with men reporting higher share of both morbidity and deaths compared to women. While the gender gap in fatalities has been similar across the globe, there have been interesting disparities in the detection of COVID-19 cases in men and women. While wealthier, more developed nations have generally seen ...
    • Building local capacity for cervical cancer prevention in low resource settings: Changing strategy during the COVID-19 pandemic 

      Salcedo, Mila P.; Varon, Melissa L.; Phoolcharoen, Natacha; Osman, Nafissa; David, Ernestina; (2021)
      In low- and middle-income countries (LMIC), where the great majority of cervical cancer cases occur, there is a shortage of health care providers trained to diagnose and treat pre-invasive cervical disease. The cervical cancer regional incidence and mortality rates are highest in sub-Saharan Africa and South-Eastern Asia [1]. In many resource-constrained ...
    • Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity 

      Hoffmann, Markus; Hofmann-Winkler, Heike; Smith, Joan C.; Krüger, Nadine; Arora, Prerna; (2021)
      Background: Antivirals are needed to combat the COVID-19 pandemic, which is caused by SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS-CoV-2 infection by blocking the virus-activating host cell protease TMPRSS2. However, antiviral activity of Camostat mesylate metabolites and potential viral resistance have not ...
    • Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2 

      El-Shennawy, Lamiaa; Hoffmann, Andrew D.; Dashzeveg, Nurmaa Khund; McAndrews, Kathleen M.; Mehl, Paul J.; (2022)
      The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the pandemic of the coronavirus induced disease 2019 (COVID-19) with evolving variants of concern. It remains urgent to identify novel approaches against broad strains of SARS-CoV-2, which infect host cells via the entry receptor angiotensin-converting enzyme 2 (ACE2). Herein, ...
    • Confident futures: Community-based organizations as first responders and agents of change in the face of the Covid-19 pandemic 

      Roels, Nastasja Ilonka; Estrella, Amarilys; Maldonado-Salcedo, Melissa; Rapp, Rayna; Hansen, Helena; (2022)
      This comparative study of community organizations serving marginalized youth in New York City and Amsterdam utilized a novel ethnographic approach called reverse engineering to identify techniques for social change that are active in each organization, adaptable and translatable to other contexts. It found that youth-serving organizations led flexible ...
    • Contact Tracing Apps: Lessons Learned on Privacy, Autonomy, and the Need for Detailed and Thoughtful Implementation 

      Hogan, Katie; Macedo, Briana; Macha, Venkata; Barman, Arko; Jiang, Xiaoqian; (2021)
      The global and national response to the COVID-19 pandemic has been inadequate due to a collective lack of preparation and a shortage of available tools for responding to a large-scale pandemic. By applying lessons learned to create better preventative methods and speedier interventions, the harm of a future pandemic may be dramatically reduced. One ...
    • COVID-19 and the value of safe transport in the United States 

      Medlock, Kenneth B.; Temzelides, Ted; Hung, Shih Yu (Elsie); Center for Energy Studies, James A. Baker III Institute for Public Policy (2021)
      We investigate the connection between the choice of transportation mode used by commuters and the probability of COVID-19 transmission. This interplay might influence the choice of transportation means for years to come. We present data on commuting, socioeconomic factors, and COVID-19 disease incidence for several US metropolitan areas. The data ...
    • COVID-19 in the Americas and the erosion of human rights for the poor 

      Hotez, Peter J.; Huete-Perez, Jorge A.; Bottazzi, Maria Elena; James A Baker III Institute for Public Policy (2020)
    • COVID-19 Vaccines: Current Conditions and Future Prospects 

      Zieneldien, Tarek; Kim, Janice; Cao, Jessica; Cao, Chuanhai (2021)
      It has been over a year since SARS-CoV-2 was first reported in December of 2019 in Wuhan, China. To curb the spread of the virus, many therapies and cures have been tested and developed, most notably mRNA and DNA vaccines. Federal health agencies (CDC, FDA) have approved emergency usage of these S gene-based vaccines with the intention of minimizing ...
    • COVID-TRACK: world and USA SARS-COV-2 testing and COVID-19 tracking 

      Zohner, Ye Emma; Morris, Jeffrey S. (2021)
      Background: The COVID-19 pandemic has caused major health and socio-economic disruptions worldwide. Accurate investigation of emerging data is crucial to inform policy makers as they construct viral mitigation strategies. Complications such as variable testing rates and time lags in counting cases, hospitalizations and deaths make it challenging to ...
    • Creation of a Global Vaccine Risk Index 

      Nuzhath, Tasmiah; Hotez, Peter J.; Damania, Ashish; Liu, P. Shuling; Colwell, Brian; (2022)
      The World Health Organization has identified vaccine hesitancy as one of its top ten global health threats for 2019. Efforts are underway to define the factors responsible for reductions in vaccine confidence. However, as global measles cases accelerated beginning in 2018, it became evident that additional factors were promoting measles re-emergence, ...
    • Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses 

      Amirian, E. Susan; Levy, Julie K.; Texas Policy Lab; Elsevier (2020)
      Recent international epidemics of coronavirus-associated illnesses underscore the urgent medical and public health need for vaccine development and regulatory body approved therapies. In particular, the current coronavirus disease 2019 (COVID-19) pandemic has quickly intensified interest in developing treatment options to mitigate impact on human ...
    • Design and proof of concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain 

      Staquicini, Daniela I.; Tang, Fenny H. F.; Markosian, Christopher; Yao, Virginia J.; Staquicini, Fernanda I.; (2021)
      Development of effective vaccines against coronavirus disease 2019 (COVID-19) is a global imperative. Rapid immunization of the entire human population against a widespread, continually evolving, and highly pathogenic virus is an unprecedented challenge, and different vaccine approaches are being pursued. Engineered filamentous bacteriophage (phage) ...
    • Developing an Effective Peptide-Based Vaccine for COVID-19: Preliminary Studies in Mice Models 

      Yang, Haiqiang; Cao, Jessica; Lin, Xiaoyang; Yue, Jingwen; Zieneldien, Tarek; (2022)
      Coronavirus disease 2019 (COVID-19) has caused massive health and economic disasters worldwide. Although several vaccines have effectively slowed the spread of the virus, their long-term protection and effectiveness against viral variants are still uncertain. To address these potential shortcomings, this study proposes a peptide-based vaccine to ...
    • DINC-COVID: A webserver for ensemble docking with flexible SARS-CoV-2 proteins 

      Hall-Swan, Sarah; Devaurs, Didier; Rigo, Mauricio M.; Antunes, Dinler A.; Kavraki, Lydia E.; (2021)
      An unprecedented research effort has been undertaken in response to the ongoing COVID-19 pandemic. This has included the determination of hundreds of crystallographic structures of SARS-CoV-2 proteins, and numerous virtual screening projects searching large compound libraries for potential drug inhibitors. Unfortunately, these initiatives have had ...