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dc.contributor.authorShin, Jaeoh
Kolomeisky, Anatoly B.
dc.date.accessioned 2019-01-18T17:51:30Z
dc.date.available 2019-01-18T17:51:30Z
dc.date.issued 2018
dc.identifier.citation Shin, Jaeoh and Kolomeisky, Anatoly B.. "Molecular search with conformational change: One-dimensional discrete-state stochastic model." The Journal of Chemical Physics, 149, no. 17 (2018) AIP Publishing LLC: https://doi.org/10.1063/1.5051035.
dc.identifier.urihttps://hdl.handle.net/1911/105101
dc.description.abstract Molecular search phenomena are observed in a variety of chemical and biological systems. During the search, the participating particles frequently move in complex inhomogeneous environments with random transitions between different dynamic modes. To understand the mechanisms of molecular search with alternating dynamics, we investigate the search dynamics with stochastic transitions between two conformations in a one-dimensional discrete-state stochastic model. It is explicitly analyzed using the first-passage time probability method to obtain a full dynamic description of the search process. A general dynamic phase diagram is developed. It is found that there are several dynamic regimes in the molecular search with conformational transitions, and they are determined by the relative values of the relevant length scales in the system. Theoretical predictions are fully supported by Monte Carlo computer simulations.
dc.language.iso eng
dc.publisher AIP Publishing LLC
dc.rights Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.title Molecular search with conformational change: One-dimensional discrete-state stochastic model
dc.type Journal article
dc.citation.journalTitle The Journal of Chemical Physics
dc.contributor.org Center for Theoretical Biological Physics
dc.citation.volumeNumber 149
dc.citation.issueNumber 17
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1063/1.5051035
dc.identifier.pmid 30409016
dc.type.publication publisher version
dc.citation.articleNumber 174104


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