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dc.contributor.authorLiu, Jing
Wada, Youichiro
Katsura, Mari
Tozawa, Hideto
Erwin, Nicholas
Kapron, Carolyn M
Bao, Gang
Liu, Ju
dc.date.accessioned 2019-01-18T16:26:53Z
dc.date.available 2019-01-18T16:26:53Z
dc.date.issued 2018
dc.identifier.citation Liu, Jing, Wada, Youichiro, Katsura, Mari, et al.. "Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis." Theranostics, 8, no. 21 (2018) Ivyspring: 6053-6069. https://doi.org/10.7150/thno.30305.
dc.identifier.urihttps://hdl.handle.net/1911/105099
dc.description.abstract Identified as a major downstream effector of the small GTPase RhoA, Rho-associated coiled-coil kinase (ROCK) is a versatile regulator of multiple cellular processes. Angiogenesis, the process of generating new capillaries from the pre-existing ones, is required for the development of various diseases such as cancer, diabetes and rheumatoid arthritis. Recently, ROCK has attracted attention for its crucial role in angiogenesis, making it a promising target for new therapeutic approaches. In this review, we summarize recent advances in understanding the role of ROCK signaling in regulating the permeability, migration, proliferation and tubulogenesis of endothelial cells (ECs), as well as its functions in non-ECs which constitute the pro-angiogenic microenvironment. The therapeutic potential of ROCK inhibitors in angiogenesis-related diseases is also discussed.
dc.language.iso eng
dc.publisher Ivyspring
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/).
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.title Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis
dc.type Journal article
dc.citation.journalTitle Theranostics
dc.subject.keywordRho-associated coiled-coil kinase (ROCK)
angiogenesis
endothelial cell
microenvironment
therapeutic target
dc.citation.volumeNumber 8
dc.citation.issueNumber 21
dc.identifier.digital v08p6053
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.7150/thno.30305
dc.identifier.pmcid PMC6299434
dc.identifier.pmid 30613282
dc.type.publication publisher version
dc.citation.firstpage 6053
dc.citation.lastpage 6069


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This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/).
Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/).