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    Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis

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    Author
    Liu, Jing; Wada, Youichiro; Katsura, Mari; Tozawa, Hideto; Erwin, Nicholas; More... Kapron, Carolyn M; Bao, Gang; Liu, Ju Less...
    Date
    2018
    Abstract
    Identified as a major downstream effector of the small GTPase RhoA, Rho-associated coiled-coil kinase (ROCK) is a versatile regulator of multiple cellular processes. Angiogenesis, the process of generating new capillaries from the pre-existing ones, is required for the development of various diseases such as cancer, diabetes and rheumatoid arthritis. Recently, ROCK has attracted attention for its crucial role in angiogenesis, making it a promising target for new therapeutic approaches. In this review, we summarize recent advances in understanding the role of ROCK signaling in regulating the permeability, migration, proliferation and tubulogenesis of endothelial cells (ECs), as well as its functions in non-ECs which constitute the pro-angiogenic microenvironment. The therapeutic potential of ROCK inhibitors in angiogenesis-related diseases is also discussed.
    Citation
    Liu, Jing, Wada, Youichiro, Katsura, Mari, et al.. "Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis." Theranostics, 8, no. 21 (2018) Ivyspring: 6053-6069. https://doi.org/10.7150/thno.30305.
    Published Version
    https://doi.org/10.7150/thno.30305
    Keyword
    Rho-associated coiled-coil kinase (ROCK); angiogenesis; endothelial cell; microenvironment; therapeutic target
    Type
    Journal article
    Publisher
    Ivyspring
    Citable link to this page
    https://hdl.handle.net/1911/105099
    Rights
    This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/).
    Link to License
    https://creativecommons.org/licenses/by-nc/4.0/
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    • Bioengineering Publications [659]
    • Faculty Publications [5245]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map