Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis
Author
Date
2018Abstract
Identified as a major downstream effector of the small GTPase RhoA, Rho-associated coiled-coil kinase (ROCK) is a versatile regulator of multiple cellular processes. Angiogenesis, the process of generating new capillaries from the pre-existing ones, is required for the development of various diseases such as cancer, diabetes and rheumatoid arthritis. Recently, ROCK has attracted attention for its crucial role in angiogenesis, making it a promising target for new therapeutic approaches. In this review, we summarize recent advances in understanding the role of ROCK signaling in regulating the permeability, migration, proliferation and tubulogenesis of endothelial cells (ECs), as well as its functions in non-ECs which constitute the pro-angiogenic microenvironment. The therapeutic potential of ROCK inhibitors in angiogenesis-related diseases is also discussed.
Citation
Published Version
Keyword
Rho-associated coiled-coil kinase (ROCK); angiogenesis; endothelial cell; microenvironment; therapeutic target
Type
Journal article
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Citable link to this page
https://hdl.handle.net/1911/105099Rights
This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/).Link to License
https://creativecommons.org/licenses/by-nc/4.0/Metadata
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