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dc.contributor.authorPantano, Naitielle
Hunt, Brady
Schwarz, Richard A.
Parra, Sonia
Cherry, Katelin
Possati‐Resende, Júlio César
Longatto‐Filho, Adhemar
Fregnani, José Humberto Tavares Guerreiro
Castle, Philip E.
Schmeler, Kathleen
Richards‐Kortum, Rebecca
dc.date.accessioned 2019-01-09T17:21:10Z
dc.date.available 2019-01-09T17:21:10Z
dc.date.issued 2018
dc.identifier.citation Pantano, Naitielle, Hunt, Brady, Schwarz, Richard A., et al.. "Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report." Photochemistry and Photobiology, 94, no. 6 (2018) 1308-1313. https://doi.org/10.1111/php.12976.
dc.identifier.urihttp://hdl.handle.net/1911/105024
dc.description.abstract Proflavine is an acridine dye used with high-resolution microendoscopy for in vivo diagnostic evaluation of cervical epithelial cells. However, there are concerns that even short-term exposure of cervical tissue to dilute proflavine may increase cervical cancer risk. We performed a retrospective analysis of women referred for colposcopy to Barretos Cancer Hospital comparing the risk of cervical disease progression in those whose cervical tissue was (n = 232) or was not exposed (n = 160) to proflavine. Patients in both groups underwent treatment and follow-up based on histopathologic results and per the local standards of care. Progression of disease was evaluated by comparing histopathology from the initial visit to the worst subsequent histopathology result from all follow-up visits. Mean duration of follow-up was 18.7 and 20.1 months for the proflavine-exposed and controls groups, respectively. There were no significant differences in disease progression from normal/CIN1 to CIN2/3 or from any initial diagnosis to invasive cancer between the proflavine exposed and control groups overall. Risks of cervical dysplasia progression observed in this study are in agreement with those of the natural history of cervical cancer. Our results suggest that cervical exposure to dilute proflavine does not increase the risk of cervical precancer and cancer.
dc.language.iso eng
dc.rights This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.title Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report
dc.type Journal article
dc.citation.journalTitle Photochemistry and Photobiology
dc.citation.volumeNumber 94
dc.citation.issueNumber 6
dc.identifier.digital Proflavine-Exposure
dc.contributor.publisher Wiley
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.1111/php.12976
dc.identifier.pmcid PMC6282608
dc.identifier.pmid 29981148
dc.type.publication publisher version
dc.citation.firstpage 1308
dc.citation.lastpage 1313


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This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.