Show simple item record

dc.contributor.advisor Clark, John W.
dc.creatorRobinson, Keith
dc.date.accessioned 2018-12-18T21:19:22Z
dc.date.available 2018-12-18T21:19:22Z
dc.date.issued 1983
dc.identifier.urihttps://hdl.handle.net/1911/104236
dc.description No page 82
dc.description.abstract Recent advances in cardiac electrophysiology have allowed for the preparation of viable single frog atrial cells. These cells have properties which make them ideal for voltage clamp studies. The ionic currents observed under voltage clamp conditons from single frog atrial cells are analyzed with the use of automatic methods programmed on a computer. From the analyzed data, mathematical models are formed which describe the time and voltage dependence of the various ionic currents observed under voltage clamp conditions. These models are then combined, and a membrane action potential is reconstructed based on the analyzed ionic current data. This membrane action potential is then used as input to a nonlinear least-squares fitting routine in an attempt to accurately fit the model to experimental action potential data.
dc.format.extent 250 pp
dc.language.iso eng
dc.title A mathematical reconstruction of the frog atrial action potential based on voltage clamp data
dc.identifier.digital RICE1865
dc.contributor.committeeMember Glantz, Raymon M.;Johnson, Don H.
dc.type.genre Thesis
dc.type.material Text
thesis.degree.department Electrical Engineering
thesis.degree.discipline Engineering
thesis.degree.grantor Rice University
thesis.degree.level Masters
thesis.degree.name Master of Science
dc.format.digitalOrigin reformatted digital
dc.identifier.callno THESIS E.E. 1983 ROBINSON
dc.identifier.citation Robinson, Keith. "A mathematical reconstruction of the frog atrial action potential based on voltage clamp data." (1983) Master’s Thesis, Rice University. https://hdl.handle.net/1911/104236.


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record