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dc.contributor.advisor Zygourakis, Kyriacos
dc.creatorLennon, Sean Patrick
dc.date.accessioned 2018-12-03T18:31:20Z
dc.date.available 2018-12-03T18:31:20Z
dc.date.issued 2008
dc.identifier.urihttps://hdl.handle.net/1911/103549
dc.description.abstract Recent studies suggest that the human immune system, and in particular lymphocyte function, may be suppressed during space flight. However, the mechanisms by which mechanical forces affect the function of immune cells are still poorly understood. Research performed in our laboratory indicates that culturing lymphocytes under low shear conditions (in rotating wall vessels) leads to an increase in cell motility and altered cell morphology. We have hypothesized that fundamental changes in the cytoskeleton, caused by changes in external forces, could lead to secondary changes in cellular metabolism, which could in turn be reflected by altered membrane structure. Utilizing NMR to investigate changes in lymphocyte function in an altered mechanical environment, we observed significant changes in cell metabolism following cell culture in the RWV, as compared to cells cultured statically. Our research seeks to advance the understanding of how microgravity affects the function of individual cells and how these cells interact with their environment.
dc.format.extent 79 pp
dc.language.iso eng
dc.subjectCellular biology
Biomedical research
Chemical engineering
Applied sciences
Biological sciences
dc.title Change in cell motility and metabolism following culture under low shear conditions
dc.identifier.digital 304508188
dc.type.genre Thesis
dc.type.material Text
thesis.degree.department Chemical and Biomolecular Engineering
thesis.degree.discipline Engineering
thesis.degree.grantor Rice University
thesis.degree.level Masters
thesis.degree.name Master of Science
dc.identifier.callno THESIS CH.E. 2008 LENNON
dc.identifier.citation Lennon, Sean Patrick. "Change in cell motility and metabolism following culture under low shear conditions." (2008) Master’s Thesis, Rice University. https://hdl.handle.net/1911/103549.


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