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dc.contributor.authorShvets, Alexey A.
Kochugaeva, Maria P.
Kolomeisky, Anatoly B.
dc.date.accessioned 2018-11-15T17:16:13Z
dc.date.available 2018-11-15T17:16:13Z
dc.date.issued 2018
dc.identifier.citation Shvets, Alexey A., Kochugaeva, Maria P. and Kolomeisky, Anatoly B.. "Mechanisms of Protein Search for Targets on DNA: Theoretical Insights." Molecules, 23, no. 9 (2018) MDPI: https://doi.org/10.3390/molecules23092106.
dc.identifier.urihttps://hdl.handle.net/1911/103343
dc.description.abstract Protein-DNA interactions are critical for the successful functioning of all natural systems. The key role in these interactions is played by processes of protein search for specific sites on DNA. Although it has been studied for many years, only recently microscopic aspects of these processes became more clear. In this work, we present a review on current theoretical understanding of the molecular mechanisms of the protein target search. A comprehensive discrete-state stochastic method to explain the dynamics of the protein search phenomena is introduced and explained. Our theoretical approach utilizes a first-passage analysis and it takes into account the most relevant physical-chemical processes. It is able to describe many fascinating features of the protein search, including unusually high effective association rates, high selectivity and specificity, and the robustness in the presence of crowders and sequence heterogeneity.
dc.language.iso eng
dc.publisher MDPI
dc.rights This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.title Mechanisms of Protein Search for Targets on DNA: Theoretical Insights
dc.type Journal article
dc.citation.journalTitle Molecules
dc.subject.keywordfirst-passage processes
protein-DNA interactions
stochastic models
dc.citation.volumeNumber 23
dc.citation.issueNumber 9
dc.identifier.digital molecules-23-02106
dc.type.dcmi Text
dc.identifier.doihttps://doi.org/10.3390/molecules23092106
dc.identifier.pmid 30131459
dc.type.publication publisher version
dc.citation.articleNumber 2106


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).