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    Radiation-Induced Cardiovascular Disease: Mechanisms and Importance of Linear Energy Transfer

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    Author
    Sylvester, Christopher B.; Abe, Jun-ichi; Patel, Zarana S.; Grande-Allen, K. Jane
    Date
    2018
    Abstract
    Radiation therapy (RT) in the form of photons and protons is a well-established treatment for cancer. More recently, heavy charged particles have been used to treat radioresistant and high-risk cancers. Radiation treatment is known to cause cardiovascular disease (CVD) which can occur acutely during treatment or years afterward in the form of accelerated atherosclerosis. Radiation-induced cardiovascular disease (RICVD) can be a limiting factor in treatment as well as a cause of morbidity and mortality in successfully treated patients. Inflammation plays a key role in both acute and chronic RICVD, but the underling pathophysiology is complex, involving DNA damage, reactive oxygen species, and chronic inflammation. While understanding of the molecular mechanisms of RICVD has increased, the growing number of patients receiving RT warrants further research to identify individuals at risk, plans for prevention, and targets for the treatment of RICVD. Research on RICVD is also relevant to the National Aeronautics and Space Administration (NASA) due to the prevalent space radiation environment encountered by astronauts. NASA’s current research on RICVD can both contribute to and benefit from concurrent work with cell and animal studies informing radiotoxicities resulting from cancer therapy. This review summarizes the types of radiation currently in clinical use, models of RICVD, current knowledge of the mechanisms by which they cause CVD, and how this knowledge might apply to those exposed to various types of radiation.
    Citation
    Sylvester, Christopher B., Abe, Jun-ichi, Patel, Zarana S., et al.. "Radiation-Induced Cardiovascular Disease: Mechanisms and Importance of Linear Energy Transfer." Frontiers in Cardiovascular Medicine, 5, (2018) Frontiers Media S.A.: https://doi.org/10.3389/fcvm.2018.00005.
    Published Version
    https://doi.org/10.3389/fcvm.2018.00005
    Keyword
    cardiovascular disease; radiation; cancer; charged particle; linear energy transfer; More... chronic inflammation; space radiation Less...
    Type
    Journal article
    Publisher
    Frontiers Media S.A.
    Citable link to this page
    https://hdl.handle.net/1911/102406
    Rights
    This is an open-access article distributed under the terms of theᅠCreative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
    Link to License
    https://creativecommons.org/licenses/by/4.0/
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    • Bioengineering Publications [659]
    • Faculty Publications [5245]

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    Home | FAQ | Contact Us | Privacy Notice | Accessibility Statement
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
    Site Map