Rice Univesrity Logo
    • FAQ
    • Deposit your work
    • Login
    View Item 
    •   Rice Scholarship Home
    • Faculty & Staff Research
    • Faculty Publications
    • View Item
    •   Rice Scholarship Home
    • Faculty & Staff Research
    • Faculty Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Adherence to treatment guidelines and survival for older patients with stage II or III colon cancer in Texas from 2001 through 2011

    Thumbnail
    Name:
    VHo_ColonCancerManuscript.pdf
    Size:
    299.1Kb
    Format:
    PDF
    View/Open
    Author
    Zhao, Hui
    Zhang, Ning
    Ho, Vivian
    Ding, Minming
    He, Weiguo
    Niu, Jiangong
    Yang, Ming
    Du, Xianglin
    Zorzi, Daria
    Chavez-MacGregor, Mariana
    Giordano, Sharon H.
    Date
    2018
    Citation
    Zhao, Hui, Zhang, Ning, Ho, Vivian, et al.. "Adherence to treatment guidelines and survival for older patients with stage II or III colon cancer in Texas from 2001 through 2011." Cancer, 124, no. 4 (2018) 679-687. https://doi.org/10.1002/cncr.31094.
    Published Version
    https://doi.org/10.1002/cncr.31094
    Abstract
    BACKGROUND: Treatment guidelines for colon cancer recommend colectomy with lymphadenectomy of at least 12 lymph nodes for patients with stage I to stage III disease as surgery adherence (SA) and adjuvant chemotherapy for individuals with stage III disease. Herein, the authors evaluated adherence to these guidelines among older patients in Texas with colon cancer and the associated survival outcomes. METHODS: Using Texas Cancer Registry data linked with Medicare data, the authors included patients with AJCC stage II and III colon cancer who were aged ?66 years and diagnosed between 2001 and 2011. SA and adjuvant chemotherapy adherence rates to treatment guidelines were estimated. The chi-square test, general linear regression, survival probability, and Cox regression were used to identify factors associated with adherence and survival. RESULTS: The rate of SA increased from 47.2% to 84% among 6029 patients with stage II or stage III disease from 2001 to 2011, and the rate of adjuvant chemotherapy increased from 48.9% to 53.1% for patients with stage III disease during the same time period. SA was associated with marital status, tumor size, surgeon specialty, and year of diagnosis. Patient age, sex, marital status, Medicare state buy-in status, comorbidity status, and year of diagnosis were found to be associated with adjuvant chemotherapy. The 5-year survival probability for patients receiving guideline-concordant treatment was the highest at 87% for patients with stage II disease and was 73% for those with stage III disease. After adjusting for demographic and tumor characteristics, improved cancer cause-specific survival was associated with the receipt of stage-specific, guideline-concordant treatment for patients with stage II or stage III disease. CONCLUSIONS: The adherence to guideline-concordant treatment among older patients with colon cancer residing in Texas improved over time, and was associated with better survival outcomes. Future studies should be focused on identifying interventions to improve guideline-concordant treatment adherence.
    Keyword
    cancer-specific survival; colon cancer; lymphadenectomy of at least 12 lymph nodes; stage II and stage III; treatment adherence
    Type
    Journal article
    Citable link to this page
    https://hdl.handle.net/1911/102312
    Metadata
    Show full item record
    Collections
    • Economics Publications [39]
    • Faculty Publications [3507]

    Home | FAQ | Contact Us
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892
     

     

    Searching scope

    Browse

    Entire ArchiveCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsTypeThis CollectionBy Issue DateAuthorsTitlesSubjectsType

    My Account

    Login

    Statistics

    View Usage Statistics

    Home | FAQ | Contact Us
    Managed by the Digital Scholarship Services at Fondren Library, Rice University
    Physical Address: 6100 Main Street, Houston, Texas 77005
    Mailing Address: MS-44, P.O.BOX 1892, Houston, Texas 77251-1892