Now showing items 1-12 of 12

    • Active patterning and asymmetric transport in a model actomyosin network 

      Wang, Shenshen; Wolynes, Peter G. (2013)
      Cytoskeletal networks, which are essentially motor-filament assemblies, play a major role in many developmental processes involving structural remodeling and shape changes. These are achieved by nonequilibrium self-organization ...
    • Chemical physics of protein folding 

      Wolynes, Peter G.; Eaton, William A.; Fersht, Alan R. (2012-10-30)
    • Dichotomous noise models of gene switches 

      Potoyan, Davit A.; Wolynes, Peter G. (2015)
      Molecular noise in gene regulatory networks has two intrinsic components, one part being due to fluctuations caused by the birth and death of protein or mRNA molecules which are often present in small numbers and the other ...
    • Fluctuating mobility generation and transport in glasses 

      Wisitsorasak, Apiwat; Wolynes, Peter G. (2013)
      In the context of the random first order transition theory we use an extended mode coupling theory of the glass transition that includes activated events to account for spatiotemporal structures in rejuvenating glasses. ...
    • Frustration in biomolecules 

      Ferreiro, Diego U.; Komives, Elizabeth A.; Wolynes, Peter G. (2014)
      Biomolecules are the prime information processing elements of living matter. Most of these inanimate systems are polymers that compute their own structures and dynamics using as input seemingly random character strings of ...
    • Funneling and frustration in the energy landscapes of some designed and simplified proteins 

      Truong, Ha H.; Kim, Bobby L.; Schafer, Nicholas P.; Wolynes, Peter G. (2013)
      We explore the similarities and differences between the energy landscapes of proteins that have been selected by nature and those of some proteins designed by humans. Natural proteins have evolved to function as well as ...
    • Microscopic theory of the glassy dynamics of passive and active network materials 

      Wang, Shenshen; Wolynes, Peter G. (2013)
      Signatures of glassy dynamics have been identified experimentally for a rich variety of materials in which molecular networks provide rigidity. Here we present a theoretical framework to study the glassy behavior of both ...
    • Molecular stripping, targets and decoys as modulators of oscillations in the NF-κB/IκBα/DNA genetic network 

      Wang, Zhipeng; Potoyan, Davit A.; Wolynes, Peter G. (2016)
      Eukaryotic transcription factors in the NF-κB family are central components of an extensive genetic network that activates cellular responses to inflammation and to a host of other external stressors. This network consists ...
    • On the hydrodynamics of swimming enzymes 

      Bai, Xiaoyu; Wolynes, Peter G. (2015)
      Several recent experiments suggest that rather generally the diffusion of enzymes may be augmented through their activity. We demonstrate that such swimming motility can emerge from the interplay between the enzyme energy ...
    • Predictive energy landscapes for folding α-helical transmembrane proteins 

      Kim, Bobby L.; Schafer, Nicholas P.; Wolynes, Peter G. (2014)
      We explore the hypothesis that the folding landscapes of membrane proteins are funneled once the proteins' topology within the membrane is established. We extend a protein folding model, the associative memory, water-mediated, ...
    • Protein Frustratometer 2: a tool to localize energetic frustration in protein molecules, now with electrostatics 

      Parra, R. Gonzalo; Schafer, Nicholas P.; Radusky, Leandro G.; Tsai, Min-Yeh; Guzovsky, A. Brenda; Wolynes, Peter G.; Ferreiro, Diego U. (2016)
      The protein frustratometer is an energy landscape theory-inspired algorithm that aims at localizing and quantifying the energetic frustration present in protein molecules. Frustration is a useful concept for analyzing ...
    • Tensegrity and motor-driven effective interactions in a model cytoskeleton 

      Wang, Shenshen; Wolynes, Peter G. (2012)
      Actomyosin networks are major structural components of the cell. They provide mechanical integrity and allow dynamic remodeling of eukaryotic cells, self-organizing into the diverse patterns essential for development. We ...