Now showing items 1-3 of 3

    • Deformable complex network for refining low-resolution X-ray structures 

      Zhang, Chong; Wang, Qinghua; Ma, Jianpeng (2015)
      In macromolecular X-ray crystallography, building more accurate atomic models based on lower resolution experimental diffraction data remains a great challenge. Previous studies have used a deformable elastic network (DEN) ...
    • Free energy landscape for the binding process of Huperzine A to acetylcholinesterase 

      Bai, Fang; Xu, Yechun; Chen, Jing; Liu, Qiufeng; Gu, Junfeng; Wang, Xicheng; Ma, Jianpeng; Li, Honglin; Onuchic, José N.; Jiang, Hualiang (2012)
      Drug-target residence time (t = 1/koff, where koff is the dissociation rate constant) has become an important index in discovering betteror best-in-class drugs. However, little effort has been dedicated to developing ...
    • Structural Basis of Actin Filament Nucleation by Tandem W Domains 

      Chen, Xiaorui; Ni, Fengyun; Tian, Xia; Kondrashkina, Elena; Wang, Qinghua; Ma, Jianpeng (2013)
      Spontaneous nucleation of actin is very inefficient in cells. To overcome this barrier, cells have evolved a set of actin filament nucleators to promote rapid nucleation and polymerization in response to specific stimuli. ...