Laser/tissue interactions

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Title: Laser/tissue interactions
Author: Valderrama, Giuseppe Luigi
Advisor: Berry, Michael J.
Degree: Doctor of Philosophy thesis
Abstract: Repetitively pulsed (rp) and continuous wave (cw) hydrogen fluoride/deuterium fluoride (HF/DF) chemical laser interactions with in vitro human corneal and cardiovascular tissue have been studied to understand tissue ablation phenomenology, effects, and mechanisms under well characterized laser irradiation conditions. Selected cw multi-line DF ($\lambda$ = 3.72 $-$ 4.05 $\mu$m), cw single-line HF ($\lambda$ = 2.91 $\mu$m), and rp multi-line HF ($\lambda$ = 2.71 $-$ 2.96 $\mu$m) chemical laser experiments were conducted. Extensive rp single-line HF chemical laser experiments at two wavelengths ($\lambda$ = 2.78 $\mu$m and 2.91 $\mu$m) over a peak fluence range of 0.5 to 10 J/cm$\sp2$ have been performed to determine ablation efficiencies and effective enthalpies of ablation ($Q\sp*$) as a function of wavelength and fluence. The experimental results have been analyzed to consider the physical and chemical processes associated with thermochemical ablation of human corneal and cardiovascular tissues by pulsed infrared lasers. Argon ion laser-induced fluorescence studies of in vitro human cardiovascular tissues have been performed to identify unique fluorescence signatures as a function of atherosclerotic progression. Extensive spectroscopic studies using $\lambda\sb{\rm ex}$ = 457.9 nm have been performed to understand tissue fluorescence and reabsorption phenomena. A variety of experiments have provided evidence that the three peak structure observed in "normal" cardiovascular tissue is the result of post-mortem diffusion of hemoglobin into the arterial wall. The experimental results have been analyzed to consider the applicability of laser-induced fluorescence as a cardiovascular diagnostic technique.
Citation: Valderrama, Giuseppe Luigi. (1990) "Laser/tissue interactions." Doctoral Thesis, Rice University.
Date: 1990

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